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OBAT SISTEM SARAF OTONOM

OBAT SISTEM SARAF OTONOM. Disampaikan Oleh : Ida Mukhlisa , S.Farm,Apt. Sistem Saraf Otonom. Secara anatomi SSO dibagi menjadi 2 bagian besar : Parasimpatis ( Kraniosakral )

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OBAT SISTEM SARAF OTONOM

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  1. OBAT SISTEM SARAF OTONOM DisampaikanOleh : Ida Mukhlisa, S.Farm,Apt

  2. SistemSarafOtonom Secaraanatomi SSO dibagimenjadi 2 bagianbesar : Parasimpatis (Kraniosakral) Secaraanatomi, serabutparasimpatisberadadikraniosakralpada spinal cord, mempunyaiserabutpreganglion yang panjangdanserabutpostganglion yang pendek. Ganglion dekatatauadapadajaringan target. 2. Simpatis (Thorakolumbar) Secaraanatomi, serabutsimpatisberadadibagianthorakolumbar spinal cord, memilikiserabutpreganglionpendekdengansinapsdalam ganglia yang membentukrantai – batangsimpatik. Sebagianbesarjarignandiinervasiolehsarafparasimpatikdansimpatik, tetapiadabeberapapengecualian.

  3. Flow Chart Sistem Saraf

  4. Reseptor Neurotransmitter SSO

  5. Jenis Reseptor Otonom

  6. Gambar 1 : Classification of cholinergic and adrenergic receptor types and subtypes.

  7. Alpha Receptor

  8. AktivitasSarafOtonomterhadapBeberapaSistem Organ

  9. 1. AgonisAdrenergikKerjaLangsung Selectivitasrelatifagonisadrenoreseptor

  10. AgonisAdrenergik

  11. 3. AgonisAdrenergikKerjaCampuran Ephedrine Alkaloid yang berasaldaritanaman, menstimulasisecaralangsungreseptor dan  sertamenstimulasipelepasannorepinephrine. Diabsorbsisecaraoral,diekskresikandalambentuk yang tidakdiubahmelaluiurin. Meningkatkanteanandarahmelaluistimulasi  dan . Merupakan bronchodilator. Ephedrine menghasilkanstimulasiringanterhadap SSP  siaga  rasa lelahdanngantuk. Digunakansebagaidekongestanjuga. Toleransidantakhfilaksisdiketahuidenganbaik. Pseudoephedrine Digunakanpadaalergi rhinitis dan flu biasa. Padadosistinggimenyebabkan TD  danmenstimulasijantung Diberikansecara oral. Jikadicampurdapatmenstimulasi SSP.

  12. AntagonisAdrenergik They are subclassified on the basis of  selectivity, partial agonist activity, local anesthetic action and lipid solubility. Classification : Non Selective  blockers: e.g. Propranolol, Satalol, PindololTimolol and Nadolol. Cardioselective  blockers: e.g. Atenolol, Acebutolol, Metoprolol, Esmolol. Drugs whick block both  and  adrenergic receptors e.g. Labetalol. Non selective  blockers with vasodilator action as carvedilol. N.B :Acebutolol, atenolol and nadolol are less lipid soluble and probably enter the CNS to a lesser extent.

  13. AntagonisAdrenergik

  14. SelektivitasRelatifAntagonisuntukAdrenoreseptor

  15. ReseptorKolinergik Reseptorkolinergikterbagi 2 type : ReseptorAChNikotinik Reseptor Ach Muskarinik Banyakdijumpaisistemsarafdiperifermaupundipusat. Keduanyaberbedadalamhaltransduksisinyalnya.

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