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Prozac Emina Hodzic period 3

Prozac Emina Hodzic period 3. Names and Chemical Formula. Prozac ( Fluoxetine Hydrochloride) IUPAC name= N-methyl-3-phenyl-3-[4-( trifluoromethyl ) phenoxy ]propan-1-amine Formula=C17H18F3NO Street names= happy pills / bottled smiles . Classification. Antidepressant

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Prozac Emina Hodzic period 3

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  1. Prozac EminaHodzic period 3

  2. Names and Chemical Formula • Prozac (Fluoxetine Hydrochloride) • IUPAC name= N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine • Formula=C17H18F3NO • Street names= happy pills / bottled smiles 

  3. Classification • Antidepressant • Selective Serotonin Reuptake Inhibitors (SSRIs). • Schedule IV drug • Currently accepted medical use in treatment in the U.S • Low potential for abuse

  4. History of Prozac • 1970s – Eli Lilly and Co. • Organic Chemists were working on finding new compounds that showed activity at serotonin receptor sites. • Came across 82816 (fluoxetine) • Continued in 1980s • Zimelidine (serotonin uptake blocker) was tested in rats and found that it helped with the addiction of morphine and alcohol. • Found that drugs that increase concentrations of brain serotonin cause animals/humans to drink less alcohol and resulted in weight loss. • Already had the name Prozac picked out. • Became secret investigation when Prozac was classified as an antidepressant instead. • Approved by the FDA in 1987

  5. Production • Prozac is made from almost entirely from fluoride. • Fluoride is the main ingredient in rat and cockroach poisons, anesthetic ,hypnotic and psychiatric drugs, and military nerve gas. • Synthetic drug • One of the most prescribed drugs in U.S • Leading antidepressant

  6. Common Abusers • Taken Orally (pill form) • Prescription is needed • Available in 10mg, 20mg and 40mg doses • Found in tablets/capsules • When abused, some cases result in amphetamine like effects, and increases energy • Abuse Drug by: • Overdose • Mix with alcohol

  7. Affects • Insomnia • Irritability • Nervousness and anxiety • Violent thoughts and actions • Agitation • Suicidal thoughts or suicide • Tremors • Hostility • Sweating • Irregular heartbeat • Aggression • Criminal behavior • Confusion and incoherent thoughts • Paranoia • Hallucinations • Psychosis • Akathisia (a painful inner agitation; inability to sit still)

  8. Continued… • Medical use: -used to treat depression -obsessive compulsive disorder (OCD) -Bulimia Nervosa -Panic Disorder • Prozac is a fluoxetine that affects neurotransmitters • An imbalance in neurotransmitters is the cause of depression

  9. Risks • Long term use leads to dependence. • LD50= 284mg/kg in mice • User goes through withdrawal if they miss a dose or stop taking the drug completely. • Withdrawal symptoms include • Dizziness • Nausea • Headaches • Vomiting • Irritability • Nightmares

  10. Detection • While on Prozac, a blood test can be taken to measure serotonin levels. • Used to see if it causes an increase/decrease in serotonin. • Brain biopsy is more accurate. • Prozac stays in the body for a long time. • Test positive for up to 3 months

  11. Consequences • Prozac is a prescription only drug. • Illegal to sell prescription drugs to other people or get them from other people • Fines • Imprisonment • Treatments: • Counseling • Doctors • Rehab

  12. Works Cited • Prozac. (2012). In Drugs.com. Retrieved December 17, 2012, from http://www.drugs.com/cdi/prozac.html • MedicineNet, INC. (2012). fluoxetine - oral, Prozac, Sarafem. In MedicineNet.com. Retrieved December 17, 2012, from http://www.medicinenet.com/fluoxetine-oral/article.htm • Hanson, D. (2009, July). The History of Prozac. In Addicition Inbox. Retrieved December 17, 2012, from http://addiction-dirkh.blogspot.com/2009/07/history-of-prozac.html • Encyclopedia Britannica INC. (2012). Prozac. In Encyclopedia Britannica. Retrieved December 19, 2012, from encyclopedia britannica • Sussex Directories, Inc. (2012). And Prozac For All. In Physcology Today. Retrieved December 19, 2012, from www.psychologytoday.com/articles/199407/and-prozac-all

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