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Inflammation p. 2

Inflammation p. 2. SYLLABUS: RBP( Robbins Basic Pathology ) Chapter : Acute and Chronic Inflammation PBD ( Pathologic Basis of Disease ) Infectious Diseases. Inflammation p. 2. 109 Miliary tuberculosis 111 Tuberculous cavity of the lung 120 Actinomycosis 151 Sarcoidosis

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Inflammation p. 2

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  1. Inflammation p.2 SYLLABUS: RBP(Robbins Basic Pathology) Chapter: Acute and ChronicInflammation PBD (PathologicBasis of Disease) InfectiousDiseases

  2. Inflammation p.2 109Miliary tuberculosis 111Tuberculous cavity of the lung 120Actinomycosis 151Sarcoidosis • Enterobiasis (appendix) • Trichinosis (muscle) 122Cysticercosis (CNS)

  3. Miliary tuberculosis (lung) • „millet seed”- size (up to 2mm) TB granulomas: • giant Langhans cells • epithelioid cells • lymphocytes • - caseous necrosis

  4. Miliary tuberculosis

  5. Miliary tuberculosis

  6. Miliary tuberculosis

  7. Tuberculous cavity of the lung the wall of a cavity: internal layer: - caseous necrosis middle layer: - components of TB granulomas outer layer: -granulation tissue -fibrous tissue

  8. Tuberculous cavity of the lung please note: the micro-slide contains a fragment of a wall of a big TB cavity, don’t search for small cavities inside that specimen

  9. Tuberculous cavity of the lung

  10. Tuberculous cavity of the lung

  11. Actinomycosis Actinomyces colonies surrounded by the purulent inflammtory infiltration

  12. Actinomycosis

  13. Actinomycosis

  14. Sarcoidosis • noncaseating granulomas • composed of: • - epithelioid cells, • - Langhans cells • - lymphocytes

  15. Sarcoidosis

  16. Sarcoidosis

  17. Enterobiasis (appendix) • Tissue: • normal mucosa • or eosinophilic reaction • or acute appendicitis • Worms: • - distinctive lateral alae („thorns” in cross section) - sections may show eggs within worms (eggs may also be seen alone)

  18. Enterobiasis (appendix)

  19. Enterobiasis (appendix)

  20. Trichinosis (muscle) • Worms: • - encysted coiled roundworms • Tissue: • muscle cells with inflammation including eosinophils and macrophages • fiber necrosis • - larval death triggers eosinophilic granulomatous inflammation leading to calcification • or • - a chronic, inactive stage where encysted organisms are found in the absence of any cellular response.

  21. Trichinosis (muscle)

  22. Trichinosis (muscle)

  23. Cysticercosis (CNS) • Worm: • fluid-filled cyst with eosinophilic laminated wall lined by monolayer of rare nuclei • older lesions fibrotic and calcified • Tissue: • - little inflammation unless ruptured

  24. Cysticercosis (CNS)

  25. Cysticercosis (CNS)

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