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Electrophysiological correlates of self-blaming bias and associated vulnerability to depression

Electrophysiological correlates of self-blaming bias and associated vulnerability to depression. Jennifer Gethin PhD Student School of Psychological Sciences Dr. Roland Zahn , Professor Wael El- Deredy , Dr. Karen Lythe. Major Depressive Disorder (MDD). Mood disorder

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Electrophysiological correlates of self-blaming bias and associated vulnerability to depression

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  1. Electrophysiological correlates of self-blaming bias and associated vulnerability to depression Jennifer Gethin PhD Student School of Psychological Sciences Dr. Roland Zahn, Professor Wael El-Deredy, Dr. Karen Lythe

  2. Major Depressive Disorder (MDD) • Mood disorder • High lifetime prevalence • Tends to be episodic • Past episode increases risk for future episode • Need to predict/prevent recurrence • Currently no functional neuroimaging marker to predict recurrence

  3. Guilt • Common symptom of depression • ‘Pathological guilt’ • Excessive • Inappropriate • Generalised

  4. PhD project • 70 participants with MDD (currently remitted) • 35 participants without history of depression • Emotional judgement task • fMRI • EEG • Longitudinal 14-month study • ~35 with recurrence of symptoms • ~35 remain stable

  5. Aim • Identify signals which differ: • control and patient groups • stable and recurrence groups • Use source localisation to locate where signal of interest originates

  6. Source analysis • Inverse problem – infinite solutions • Constrain EEG analysis using fMRI analysis as a guide • Known anatomical areas of interest from previous fMRIstudy and current study • Bayesian methodology

  7. Ultimate aim • Neurofeedback paradigm • Normalise signal to prevent recurrence • EEG is cheap and widely available

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