side view top view

1. side view top view Nicotinic acetylcholine receptor crystal structure with 4Å resolution by cryoelectron microscopy (PDB 2BG9). Figure adapted from Unwin (2005) J Mol Biol346: 967. Figure altered with MDL Chime. “Peptide Based Chloride Specific Nano Tubes”

2. NH2 COOH Peptides based on the M2 transmembrane segments nAChR and M2GlyR form channels in planar lipid bilayers with selectivity and conductance properties similar to the parent channels M1 M2 M3 M4

6. A

8. NC-1080 side N-terminus C-terminus NC-1096

9. 0 ns 0.5 ns 1 ns NC-1080 WT Top-View 1.5 ns 2 ns 2.9 ns

10. 0 ns 0.5 ns 1 ns NC-1080 WT Bottom-View 1.5 ns 2 ns 2.9 ns

11. 0 ns 0.5 ns 1 ns NC-1096 (S22W) Side-View 1.5 ns 2 ns 2.9 ns

12. 0 ns 0.5 ns 1 ns NC-1096 (S22W) Top-View 1.5 ns 2 ns 2.9 ns

13. 0 ns 0.5 ns 1 ns NC-1096 (S22W) Bottom-View 1.5 ns 2 ns 2.9 ns

15. Dept. of Physics, • Kansas State University • Dr. Talat Rahman • Dr. Ahlam Al-Rawi Dept. of Biochemistry, Kansas State University • Dr. James Broughman • Dr. Gabe Cook • Alvaro Herrera, M.S. • Dr. Takeo Iwamoto • Dr. Om Prakash Dept. of Anatomy and Physiology, Kansas State University • Dr. Bruce Schultz Research support : PHS-NIH grantsGM43617 and GM74096