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Lecture 18 Humoral Immune Response. The Antibody Response. Antibody Protection of the Host. Immunologic Memory. Virgin lymphocyte pool . PRIMARY RESPONSE . effector cells . memory cell pool . SECONDARY RESPONSE. effector cells . memory cell pool . Immunologically Naive.
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Immunologic Memory Virgin lymphocyte pool PRIMARY RESPONSE effector cells memory cell pool SECONDARY RESPONSE effector cells memory cell pool
Immunologically Naive No previous experience No memory Must be educated
The Primary Immune Response antibody titer lag log phase plateau decline time antigen challenge
Class Switching antibdy titer IgM IgG time
Four phases of the primary response • a lag phase where no antibody is detected • a log phase in which the antibody titer rises logarithmically • a plateau phase during which the antibody titer stabilizes • a phase (decline) during which the antibody is cleared or catabilized
The Anamnestic Immune Response Secondary Response antibody titer 1000 100 Primary Response 10 1 Time
Comparison of Primary and Secondary Responses • Time course • Antibody titer • Antibody class • Antibody affinity
Terms to remember • Opsonization • Neutralization • Complement activation • Primary response • Secondary/ anamnestic/ booster response • Lag phase • Log phase • Plateau period • Memory cells • Class switching • Affinity maturation/ change in affinity with time