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Antigen recognition in adaptive immunity

Antigen recognition in adaptive immunity. Mechanism of diversity of antigen receptors Maturation and selection of B lymphocytes Maturation and selection of T lymphocytes. Cells display several types of receptor and each of them is specific for a certain ligand.

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Antigen recognition in adaptive immunity

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  1. Antigen recognition in adaptive immunity Mechanism of diversity of antigen receptors Maturation and selection of B lymphocytes Maturation and selection of T lymphocytes

  2. Cells display several types of receptor and each of them is specific for a certain ligand Cells within one clone display only one type of receptor specific for a certain ligand

  3. Antigen receptors on lymphocytes B cell T cell Antigens: proteins, polysaccharides, lipids, nucleic acids, small molecules Conformational and linear epitops Complex of peptide-MHC molecule on an APC Linear epitops

  4. N N N N C C C C

  5. CDR1 CDR1 CDR2 CDR2 CDR3 CDR3 k l a (a1 a2) g (g1 g2 g3 g4) d e m VH VH VL VL CL CL Isotype IgA(1,2) IgG(1,2,3,4) V (variable) region VLi VH IgD CH CH IgE C (constant) region CL i CH IgM

  6. Antibodies • structure • function

  7. T-cellreceptor for antigen (TCR) structure

  8. Lymphocyte maturation

  9. The Nobel Prize in Physiology or Medicine 1987 "for his discovery of the genetic principle for generation of antibody diversity" Susumu Tonegawa

  10. Inherited configuration of gene loci for antigen receptors

  11. Nasleđenakonfiguracijagenskih lokusaza antigenskereceptore

  12. Recombination and expression of immunoglobulin genes

  13. 54 ~100 67 27 Mechanisms of creation of antigen receptor diversity 61 4

  14. Every day 109 lymphocytes with 107 variousspecificities are generated (young)

  15. Phases of B-cell maturation and selection

  16. Phases of B-cell maturation and selection

  17. Phases of B-cell maturation and selection

  18. Phases of B-cell maturation and selection

  19. Phases of B-cell maturation and selection

  20. T-cell maturation in thymus

  21. T-cell maturation in thymus

  22. Faze u sazrevanju i selekciji T-limfocita

  23. 1. TCR gene recombination a. eliminates auto-reactive lymphocytes 2. Negative selection b. proteins, polysaccharides, lipids 3. TCR recognizes c. aandb,organddchains 4. Immunoglobulin gene recombination d. peptides within MHC molecule 5. TCR consists of e. constant region of heavy chains 6. Antibody has f. variable regions of heavy and light chains 7. Different isotypes have the same g. occurs only in thymus 8. Positive selection h. provides antibody diversity 9. Antibody can recognize i. two identical heavy and two identical light chains 10. Receptors of different clones of B cells have different j. enables survival of useful lymphocytes g a d h c i e j b f 1.____ 2.____ 3.____ 4.____ 5.____ 6.____ 7.____ 8.____ 9.____ 10.____

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