A RARE CASE OF MULTIPLE CYSTIC METASTASES IN THE BRAIN FROM ADENOCARCINOMA OF THE LUNG

1. A. HRICHI, S. KOUKI, M. LANDOULSI ,R. AOUINI,  I. GANZOUI, S.BOUGUERRA, Y. AROUS, H. BOUJEMAA, N. BEN ABDALLAH Radiology service, Main Military hospital of Instruction of Tunis, Tunisia A RARE CASE OF MULTIPLE CYSTIC METASTASES IN THE BRAIN FROM ADENOCARCINOMA OF THE LUNG CH7

2. Inroduction: Severaldiseasescan present with multi-cystic brain lesions: • True cysts • Abscess formations • Cysticercosis • Fungal infections • Cerebral tumors • Metastases…

3. Radiologistrole? 1- Positive diagnosis easy! 2- Approach of etiologicdiagnosis: the main question!

4. Case report: A rare case of cystic intracerebral metastases from adenocarcinoma of the lung

5. ♂ • 49 yearsold • No medical histories • Smoking patient • Presented with progressive dizziness and equilibrium disorders that had developed for 5 days.

6. Neurological examination: • cerebellar syndrome • no other focal signs Biology: • Lymphocytes:  ↓ • Alkaline phosphatase: ↑ • Other laboratory studies: normal CT brain Scan was indicated

7. CT brain scan without(a) and with(b) injection of iodinated contrast: multifocal hypodense lesions(a) with partial peripheral contrast enhancement(b) but without significant perifocaloedema. Imaging findings: a1 b1 a2 b2

8. Further brain MRI was performed and allowed to objectify: multifocal cystic lesions with partial peripheral contrast enhancement but without significant perifocaloedema.

9. a1 a2 a3 b1 b2 b3 Axial T1-weighted with (a1, a2, a3) and without gadolinium (b1, b2, b3):nodularhypointense multiple extra-axial lesions, with partial peripheral contrast enhancement.

10. a1 a2 a3 b1 b2 b3 Axial T2-weighted (a1, a2, a3) and FLAIR (b1, b2, b3): Multiple hyper-T2 hypo-FLAIR extra-axial lesions (cysticlesions).

11. a1 a2 a3 b1 b2 b3 axial diffusion (a1, a2, a3) and ADC (b1, b2, b3): Multiples nodularlesionshyperintense in diffusion with a low ADC.

12. In total: • ♂ • 49 yearsold • No medical histories • Smoking patient • Lc ↓ , PAL ↑ • multi-cystic brain lesions (CT – MRI) ????

13. In total: • ♂ • 49 yearsold • No medical histories • Smoking patient • Lc ↓ , PAL ↑ • multi-cystic brain lesions (CT – MRI) ???

14. In total: • ♂ • 49 yearsold • No medical histories • Smoking patient • Lc ↓ , PAL ↑ • multi-cystic brain lesions (CT – MRI) ??

15. In total: • ♂ • 49 yearsold • No medical histories • Smoking patient • Lc ↓ , PAL ↑ • multi-cystic brain lesions (CT – MRI) ?

16. Lung cancer? In total: • ♂ • 49 yearsold • No medical histories • Smoking patient • Lc ↓ , PAL ↑ • multi-cystic brain lesions (CT – MRI)

17. a CT-chest-scan revealed a lungular small nodule not exceeding 12mm of main line with no other secondary locations • Stereotaxic brain biopsy confirmed a well-differentiated lung adenocarcinoma

18. Discussion: • Brain lesions in patients with known malignancies are suspicious for metastases; → usually: as well-circumscribed densely enhancing masses with surrounding vasogenic edema. • Cystic brain lesions are unusual; → can be misdiagnosed as: brain abscesses, primary cerebral tumors, or parasitic infections, especially in patients without a history of malignancy.

19. Cystic cerebral metastases have been described in carcinomas of : • Thymus • Breast • Prostate • Pancreas

20. However, and in reviewing the literature: -We have only found 2 similar cases reports of lung adenocarcinoma with cystic cerebral metastases. -In both of them, the patients were already followed for bronchial adenocarcinoma. - while in our case, cystic cerebral metastases revealed the disease.

21. Conclusion: This case demonstrates an unusual pattern of cerebral metastases of a bronchial adenocarcinoma. This constellation should be considered in the differential diagnosis of cerebral cystic lesions even in patients without a history of malignancy, and wich is necessary to evoke at every smoking adult's of about forty. The exact nature of which might be difficult to assess without biopsy.

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