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Muscle Anatomy. Anatomy and Physiology L2/L3. Long, thin & multinucleated Striated Involuntary Contracts rhythmically Found in cardiac tissue. Voluntary Contractions are slow and steady Walls of visceral organs & blood vessels Contract rapidly & vigorously.
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Muscle Anatomy Anatomy and Physiology L2/L3
Long, thin & multinucleated Striated Involuntary Contracts rhythmically Found in cardiac tissue Voluntary Contractions are slow and steady Walls of visceral organs & blood vessels Contract rapidly & vigorously Lets Review!!What type of muscle tissue does each describe?
Functions of skeletal muscle • Movement: of skeleton by use of muscles acting in pairs or groups • Posture Maintenance: keeping upright • Heat generation: product of movement. Serves to maintain norm. body temp (homeostasis)
Gross Anatomy of skeletal muscle • muscle cell aka (fiber): made up of many myofibrils • Epimysium (deep fascia: outer, toughest covering of Dense connective tissue • Fascicles/fasciculus :name given to bundles of muscle fibers/cells
Myofibril: many make up a cell/fiber Sarcolemma (plasma membrane): it is the cell membrane surrounding cell/fiber SR: similar to ER Sarcomere: contractile units making up myofibrils containing actin &myosin. -Multi-nucleated Anatomy of skeletal muscle (cont)
Thread-like protein structures 2 types: Thick– Myosin Thin – Actin Alternating light/dark create striations Allow muscle to contract (shorten) and relax (lengthen) Myofibril: many sarcomeres make up the myofibrils
NM Jxn Terminal end stores ACh ACh released into fiber ACh acts as stimulus Chemical Part of Muscle Contraction: Motor Unit: Composed of motor neuron & all the muscle fibers
Steps in Muscle Contraction • Nerve impulse travels down motor neuron to NM junction • Acetylcholine (ACh) released into muscle • ACh diffuses across muscle fiber • Signals the SR to release stored Calcium • Ca initiates formation of cross bridges between Actin and Myosin • *Ca stimulates a change in actin shape 6. sacrcomeres shorten and muscle fibers contract
Steps in Muscle Relaxation • Motor neuron impulse to stop contraction so Ach is inactivated. • Ca moves (Active transport) back into SR (to be stored) (*ATP) • Absence of Ca causes crossbridges to break because actin changes back its shape (*ATP) • Actin filaments slide back • RESULT: Muscle relaxes
Homework: #1and #2 • #1 Based on knowledge of muscle physiology; what steps must or do not occur in the condition Rigor Mortis at the chemical level and what happens to the body? • #2. What causes Botulism?and how might we (humans) come in contact with the toxin? • What physiological/chemical effects can Botulism have? What treatments?
Homework: #3 and #4 • #3. Look up compartment syndrome • Cause: what happens at the chemical level? • symptoms • Treatment • #4. Look up multiple sclerosis • Be able to discuss: • Cause; and what happens at the chemical level? • symptoms • treatment
Homework: #5 Muscular Dystrophy • Protein structure of muscle is mainly Actin & Myosin. • What is the function of dystrophin? • Muscular Dystrophy? • Cause: at the chemical level? • Types? • Physiological effects on body
Take a Break and Review! • Go to following animation • www.brookscole.com/chemistry_d/templates/student_resources/shared_resources/animations/muscles/muscles.html • Great animations and review activities!
Quick Quiz: 18 pts (3 each) • 1. Describe each: epimysium, fascicles, fiber/cell, sarcoplasm • 2. Explain where the sarcomere is and what is has to do with muscle contraction • 3. What has to happen in order for a body part to move?
Quiz cont. • 4. What happens at the neuromuscular junction? • 5. Explain steps in muscle contraction • 6. Explain steps in muscle relaxation