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Water. Necessary for lifeMust move from place to place which requires passagewaysblood vessels lymphatic vesselsAlso requires pressureBPosmotic pressure. BP. aka hemodynamic pressureHighest as blood is ejected from L ventricle
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1. Disorders of Fluid Balance & Blood Flow
2. Water Necessary for life
Must move from place to place which requires passageways
blood vessels
lymphatic vessels
Also requires pressure
BP
osmotic pressure
3. BP aka hemodynamic pressure
Highest as blood is ejected from L ventricle & gradually decreases as it makes its way to the R atrium
Determined by CO & vascular resistance
BP = CO X vascular resistance
Aids in blood flow & diffusion
4. Osmotic Pressure Amount of pressure to prevent H2O movement across membrane
High concentration of solute = high osmotic pressure
7. Major Determinants of Disease Fluid moves in & out of compartments with respect to the balance of osmotic & hemodynamic pressures
Injury causes increased blood flow to the injured part
Blood stays within the vessel because of the physical integrity of the vessel wall & normal coagulation function
Coagulation is a normal process that takes place outside of the vessel while intravascular coagulation is always pathologic
Thrombosis is always intravascular & always pathologic
Obstruction of arterial blood flow causes infarction
Normal blood flow requires adequate BP
8. Edema H2O moves from the vessel into tissue spaces
May be due to low plasma osmotic pressure or increased intravascular pressure
Anasarca is a severe, generalized edema
9. Local edema named for the site