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Improving bone and cardiovascular health. Investor Presentation 1. Quarter 2008. Exclusive strategic partnership agreement with Sumitomo Corp. to develop, market and sell the natural Vitamin K2
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Improving bone and cardiovascular health Investor Presentation 1. Quarter 2008
Exclusive strategic partnership agreement with Sumitomo Corp. to develop, market and sell the natural Vitamin K2 • Exclusive Research & Science contract with VitaK (Maastricht University), the world leading research-company in vitamin K. • R&D is focused on developing K2 products in addition to build IPR to secure long-term market access • Vitamin K2 is needed for optimal body utilization of Calcium and has documented beneficial effects on both Osteoporosis and Cardiovascular diseases
NattoPharma focuses on Sales & Product Development, through own Product IPR- based on clinical studies (GCP), leaving the production to Sumitomo. • Product development may also be carried out in collaboration with End-clients, depending upon customer and market requirements. End-client Sumitomo Corp. Production & Process IPR Clinical Studies IPR Product- Development Based on research Product-design End-product S&M NattoPharma
Teeth Calcification in health and disease:NattoPharma focus - + Lungs Kidneys + + • Scientific evidence: • Loss of calcification in bones; • Increased calcification heart, • arteries and in joints: • Osteoporosis • Cardiovascular disease • Osteoarthrosis Bone and cardiovascular health Normal condition: 99% of all Ca in bones & teeth; 1% in circulation Prevention & Treatment
The calcium paradox Relationship osteoporosis - arterial calcification Function of both proteins needed for optimal health Osteocalcin Matrix Gla Protein • MGP synthesised in • chondrocytes in • cartilage, and vascular • smooth muscle cells in • arteries • Inhibits soft tissue • calcification, including • cartilage mineralization • OC synthesised in osteoblasts • Glu residues carboxylated • to Gla-residues which bind Ca++ • Binds Ca++ to hydroxyapatite in bones x x x
Market opportunities • NattoPharma market strategy • NattoPharma is working to include vitamin K2 in already existing global leading brands in the Dietary supplement (ex. Multivitamins, Calsium & Omega3) Functional Food marked (Dairy-products). Thus, the revenue from the clients has the potential to go from zero to 3-diget million figure, only during the first year after signing with a large client. • Dietary supplement • Stand-alone / combination (Multivitamins, Calcium, Omega-3 and Vitamin D) • Fortified food • Fortified food with vitamins and minerals (Dairy segment, drinks) • Pharmacy • Strategy is to co-operate with a strategic partner
Market strategy Sell MenaQ7 as an ingredients into all ready existing global leading brands in the following market segments: Pharmacy Volum vitamin K2 Fortified Food Dietary supplement 2007 2008 2009 2010 2011 2012 2013
Headlines 1Q08 R&D: • Commenced clinical study combining MenaQ7 with Omega- and with Krill • Longtime study approved and ready to start for postmenopausal 240 women to see MenaQ7’s effect on bone structure and cardio vascular effects.
Headlines 1Q08 MARKET: • Have signed distribution agreements in all European countries that we are able to MenaQ7 • Focus on Food segment both in USA. Official launch of MenaQ7 in Food at world larges Food Fair, Institute of Food Technology 2008 in New Orleans. • Screening the market outside Europe and USA for potential distributors
Strategic Partnership Agremments • LOI sign with Bayer ConsumerCare • Bayer is no. 2 largest player in the global OTC market • The Parties wants to negotiate about signing a global partnership agreement for MenaQ7. • In search for a global partner also in the Food Market
Figures 1. quarter 2008 Revenues NOK 5,1m (NOK 7,4m) EBIT NOK -5,9m (NOK -0,8m) Gross margin 55,1% (56,4%)
Outlook • Expect EFSA approval during the summer • Increase the investment in R&D going forward • Reiterate revenue expectation for 2008 of between NOK 80 – 90 mill in 2008 • Expect positive EBIT in 2008