1 / 15

Hoogtepunten APA 22 mei 2008 Stemmingsstoornissen

22/05/2008. Hans van den Ameele - hoogtepunten APA . 2. Highlights APA - 22 mei 2008 Stemmingsstoornissen. vraagstelling: controverse antidepressiva ? selectie presentaties algemene indruk highlights ?. 22/05/2008. Hans van den Ameele - hoogtepunten APA . 3. Highlights APA - 22 mei 2008 Stemmin

hova
Download Presentation

Hoogtepunten APA 22 mei 2008 Stemmingsstoornissen

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


    1. 22/05/2008 Hans van den Ameele - hoogtepunten APA 1 Hoogtepunten APA 22 mei 2008 Stemmingsstoornissen Hans van den Ameele

    2. 22/05/2008 Hans van den Ameele - hoogtepunten APA 2 Highlights APA - 22 mei 2008 Stemmingsstoornissen vraagstelling: controverse antidepressiva ? selectie presentaties algemene indruk highlights ?

    3. 22/05/2008 Hans van den Ameele - hoogtepunten APA 3 Highlights APA - 22 mei 2008 Stemmingsstoornissen Psychiatric issues in women through the adult life-cycle (industry supported symposium Wyeth) An interactive symposium: unlocking the combination moving toward a better understanding of major depressive disorder (Wyeth) Novel and current antidepressants: state of the art management of depression (Novartis) Focus live: major depressive disorder Research advances in psychiatry: mood disorders (Helen Mayberg) Depression and generalized anxiety: research planning for the DSM-V (symposium)

    4. 22/05/2008 Hans van den Ameele - hoogtepunten APA 4 Highlights APA - 22 mei 2008 Stemmingsstoornissen Cellular plasticity cascades: a window into mood disorders (lecture, Husseini Manji) Research advances: Brain mechanisms of bipolar disorder and major depression (symposium) Tales of music and the brain (lecture, Oliver Sacks) Prozac and the Spiritual Self (lecture, Dan Blazer) Diagnosis - validity (scientific and clinical report session) Primary care depression management (issue workshop) New research poster session: anxiety and mood disorders

    5. 22/05/2008 Hans van den Ameele - hoogtepunten APA 5 Depression and generalized anxiety: research planning for the DSM-V diagnostische/nosologische relatie GAD-MDD ? ? vormen van één ziekte of ? ziekte empirische data ? nosologie ? ‘validators’ ? cultuur, genetica, neurobiologie, verloop, behandeling,… DSM: descriptief ? etiologisch ? essentialisme vs nominalisme categoriaal vs continuüm ‘test-case’ Validators: externe correlaten van zikete, niet betrokken bij procesValidators: externe correlaten van zikete, niet betrokken bij proces

    6. 22/05/2008 Hans van den Ameele - hoogtepunten APA 6 Depression and generalized anxiety: research planning for the DSM-V cultuur (Stein) ‘culture bound disorders’ ? ‘disease’ vs ‘illnes’ GAD ? MDD genetica (Kendler) familie en 2-ling studies: omgeving bepaalt verschil GAD en MDD: verschillende vorm van zelfde aandoening neurobiologie (Nemeroff) GAD ? MDD: specifieke neuro-anatomische en functionele stoornissen Validators: externe correlaten van zikete, niet betrokken bij procesValidators: externe correlaten van zikete, niet betrokken bij proces

    7. 22/05/2008 Hans van den Ameele - hoogtepunten APA 7 Depression and generalized anxiety: research planning for the DSM-V verloop (Kessler) National Comorbidity survey: lifetime prev. MDD: 28.8% - GAD: 11.9% ? ‘onset risk reciprocity’ - risico factoren – persistentie – stabiliteit GAD en MDD: ? maar verwante aandoeningen behandeling (Kupfer) pooled effect size van studies: ‘shared treatment response’ ? GAD: subtype MDD goede validator ? betere diagnostische dissectie ? conclusie ? different but "closely-related" Validators: externe correlaten van zikete, niet betrokken bij procesValidators: externe correlaten van zikete, niet betrokken bij proces

    8. 22/05/2008 Hans van den Ameele - hoogtepunten APA 8 Cellular plasticity cascades: a window into mood disorders (Husseini Manji) neurobiologie van ernstige stemmingsstoornissen niet: ‘imbalance in neurotransmitters in the brain’, maar: ‘disorder of synapses and circuits’ - ‘impairments of synaptic and neural plasticity - in cellular plasticity cascades' nieuwe R/: ‘therapy inside the cell’ – ‘endophenotype strategy’ targeting cellular resilience molecules optimale R/ bij therapie resistentie: neurotrofisch en neurochemisch ‘restore circuitry so neurotransmitters can do their job’

    9. 22/05/2008 Hans van den Ameele - hoogtepunten APA 9 Cellular plasticity cascades: a window into mood disorders huidige AD: delay adaptatie in intracellulaire (neurotrofische) cascades indirect effect op synaptische en neuronale plasticiteit via NMDA en AMPA receptoren (glutamaat) stemmingsstabilisatoren Li en valproaat: neuroprotectieve en neurotrofische effecten NMDA, glutamaat, PKC, GSK-3, IMPAse, Bcl-2, … neurogenese: MRI studies neurobiologie ? genetisch onderzoek turn on/off genes (BAG-1 FKBP5) neurotrofische molecules als targets: BDNF, Bcl-2,… ? nieuwe R/: directe invloed op NMDA/AMPA receptoren, PKC, Bcl-2,….

    10. 22/05/2008 Hans van den Ameele - hoogtepunten APA 10 Cellular plasticity cascades: a window into mood disorders PKC-inhibitoren (Proteine Kinase C) Li, valproaat, tamoxifen, bryostatin-I, ruboxistaurin tamoxifen: significante verbetering manie vanaf 5e dag NMDA receptor antagonist ketamine ketamine iv bij ernstige depressieve Pt: na 24 uur: 70% responders (HDRS) glutamaat inhibitie, AMPA ? riluzole Bcl-2 - neurotrophic/neuroprotective protein lithium (? bcl-2) – valproaat ? rol in AD respons ?

    11. 22/05/2008 Hans van den Ameele - hoogtepunten APA 11 Cellular plasticity cascades: a window into mood disorders

More Related