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INFLAMMATION and YOUR HEALTH

INFLAMMATION and YOUR HEALTH. Angelita B. Frando, MD Board Certified in Family Medicine Board Certified , Medical Acupuncture. Definition:. complex biological response to harmful stimuli (pathogens, damaged cells or irritants)

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INFLAMMATION and YOUR HEALTH

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  1. INFLAMMATION and YOUR HEALTH Angelita B. Frando, MD Board Certified in Family Medicine Board Certified , Medical Acupuncture

  2. Definition: • complex biological response to harmful stimuli (pathogens, damaged cells or irritants) • Protective attempt to remove the injurious stimuli and initiate the healing process • Important for survival • Causes wounds and infections to heal (acute) • Chronic = progressive destruction of tissue =>disease and degenerative changes

  3. Manifestations (Signs): • Calor (Heat) • Rubor (Redness) • Tumore (Swelling) • Dolor (Pain) • Functio laesa (loss of function)

  4. Causes: • Burns • Chemical irritants • Frostbite • Toxins • Infection by pathogens • Physical injury, blunt or penetrating • Immune reactions due to hypersensitivity • Ionizing radiation • Foreign bodies (ie., splinters, dirt and debris) • Stress • Trauma • Alcohol

  5. Types: Acute & Chronic • Names Based on body systems / organs involved: ( “-itis”) • Appendicitis • Arthritis • Bursitis • Colitis • Cystitis • Dermatitis • Myositis • Meningitis • Tendonitis • Tonsillitis • Vasculitis

  6. Acute vs Chronic Causative agent: • Bacteria, injured tissues • Immediate onset • Duration: Few days • Outcome: • Resolution, abscess, or chronic inflammation • Persistent acute inflammation, viruses, persistent foreign bodies, autoimmune reactions • Delayed Onset • Up to many months or years • Outcome: • Tissue destruction, fibrosis, necrosis

  7. Process of Acute Inflammation: • Injury/pathogen => cells activated to release inflammatory mediators: • Vasodilatation => Increased blood flow => redness and heat • Increased blood vessel permeability => leakage of plasma proteins and fluid into tissues (swelling) • Some mediators increase sensitivity to pain • Other biochemical reactions occur (complement system, coagulation and fibrinolysis systems, etc.)

  8. Cell derived mediators: • Lysosome granules • Histamine • Interferon (cytokines) • IL-8 (Interleukin 8) • Leukotriene B4 • Nitric oxide • Prostaglandins • TNF-alphaand IL-1

  9. Inflammatory Markers: • CRP (C-reactive protein) • Increased levels associated with increased risk of heart attacks, strokes, high blood pressure, muscle weakness and fragility • ESR (erythrocyte sedimentation rate) • Homocysteine levels • Tumor necrosis factor –alpha (TNF-@) • Interleukin 6, 8, 18 (IL-6, IL-8, IL18) • Blood glucose, insulin and leptin (especially for obese)

  10. Disorders associated with Inflammation: • Acne vulgaris • Allergies • Asthma • Atherosclerosis • Autoimmune disease • Cancer • Celiac disease • Chronic prostatitis • Degenerative arthritis, • Hypersensitivities • Interstitial cystitis • Inflammatory bowel / Digestive tract disordes (Pancreatitis, Crohn’s disease, Regional enteritis, Enteropathies, Hepatitis, etc.) • Kidney diseases (Diabetic Nephropathy, Glomerulonephritis, etc) • Myopathies • Obesity • Osteoporosis • Pelvic inflammatory disease • Reperfusion injury • Rheumatoid arthritis , Lupus, and other connective tissue disorders • Skin: Psoriasis, Dermatitis • Sarcoidosis • Transplant rejection • Vasculitis

  11. Medications vs Inflammation • Aspirin • Works on prostaglandins • Watch for gastrointestinal ulcers and bleeding • NSAIDS • May cause gastric/duodenal ulcers • May damage kidneys with prolonged use • Cox-2 inhibitors • Steroids: • Problems with prolonged use • Weight gain, metabolic syndrome, gastric ulcers, blunts adrenal function, etc.

  12. Supplements vs Inflammation • Arthritis: • OPC3 • Omega 3 • Glucosatrin (Boswellia with Cox-2 inhibition)

  13. Supplements vs Inflammation • Acne vulgaris: • Prevaderm • Digestive enzymes

  14. Supplements vs Inflammation • Asthma/ Allergies: • OPC3 • Aloe • ORAC

  15. Supplements vs Inflammation • Atherosclerosis • OPC3 • Heart Health • Omega 3 • Activated Vitamin B • Resveratrol

  16. Supplements vs Inflammation • Autoimmune diseases: • OPC3 • Omega 3 • Resveratrol (do not give with Coumadin or breast cancer) • Co-Q-10 • Vitamin B • Multivitamins/Minerals

  17. Supplements vs Inflammation • Cancer • During remissions • Breast Cancer • B complex • Vitamin D3 • Calcium • CoQ-10 • OPC3 • Multivitamins/multiminerals

  18. Supplements vs Inflammation • Cancer • During remissions (not during treatment) • Colon Cancer • Resveratrol • Fiber powder • B complex • CoQ-10 • OPC3 • Multivitamins/multiminerals

  19. Supplements vs Inflammation • Celiac disease • Digestive enzymes • Aloe

  20. Supplements vs Inflammation • Degenerative arthritis: • Omega 3 • OPC3 • Glucosatrin

  21. Supplements vs Inflammation • Inflammatory GI/bowel disorders, etc. • Crohn’s disease – OPC3, Digestive enzymes, Aloe • Irritable Bowel Syndrome – OPC3, Aloe, Digestive enzymes • Diverticulitis – (after bowel rest and antibiotics) Aloe, Digestive enzymes, fiber powder (for diverticulosis), OPC3 • Pancreatitis – Digestive enzymes • Gastric / Duodenal Ulcer – Aloe, Digestive enzymes • Hepatitis – Digestive enzymes, Hepatocleanse

  22. Supplements vs Inflammation • Kidney disease due to diabetes: • OPC3 • Interstitial cystitis • OPC3

  23. Supplements vs Inflammation • Osteoporosis: • Calcium plus • Vitamin D3 with K2 (IF Vitamin D deficient) • D3 levels should be optimally placed at around 40-60 nmol/l • Monitor blood levels to avoid toxicity

  24. Supplements vs Inflammation • OBESITY: • Associated with chronic inflammation • Waist circumference correlates to inflammatory response • OPC3 • Resveratrol • Omega 3 • Transitions

  25. Supplements vs Inflammation • Reperfusion Injury (Heart and Brain): • Post- Myocardial infarction and Post-Stroke • OPC3 • Resveratrol • Omega 3 • Psoriasis: • OPC3

  26. Keep Inflammation in moderation

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