1 / 9

Magnetically-Guided Nanoparticles for Targeted Drug Delivery

Magnetically-Guided Nanoparticles for Targeted Drug Delivery. Presentation for RET program July 7, 2011 Seth Baker Advisors: Dr . Andreas Linninger , Eric Lueshen , Madhawa Hettiarachchi Laboratory for Product and Process Design University of Illinois- Chicago

jasia
Download Presentation

Magnetically-Guided Nanoparticles for Targeted Drug Delivery

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Magnetically-Guided Nanoparticles for Targeted Drug Delivery Presentation for RET program July 7, 2011 Seth Baker Advisors: Dr. Andreas Linninger, Eric Lueshen, MadhawaHettiarachchi Laboratory for Product and Process Design University of Illinois- Chicago Department of Chemical Engineering University of Illinois Chicago, LPPD, Summer 2011

  2. Project Summary • Neurological therapeutics have limited success due to natural barriers such as the blood brain barrier. Methods to circumvent or penetrate the blood brain barrier include: • Receptor- Mediated Transport Molecular Trojan Horses • Intranasal Osmotic Disruption • Convection-Enhanced Delivery Macrophage Transport • Over 7 million Americans suffer from neurological conditions such as Alzheimer’s, Parkinson’s, Brain Cancer, and Stroke. These conditions have direct and indirect costs of over $200 billion dollars annually in the United States. • Magnetically – guided nanoparticles could offer targeted detection, diagnosis and treatment options for these neurological conditions. University of Illinois Chicago, LPPD, Summer 2011

  3. Benefits of Magnetic Nanoparticles • Allows for more targeted drug delivery resulting in lower dosage and systemic toxicity. Particles are biocompatible and biodegradable. • Nanoparticles can be coated or loaded with various therapeutics. University of Illinois Chicago, LPPD, Summer 2011

  4. Determine Magnetic Quality Magnetite nanoparticles were guided toward a 173 lb pull force magnet over an 8 minute experiment. Time = 0 sec Time = 60 sec Time = 120 sec Time = 180 sec Time = 300 sec Time = 420 sec Time = 360 sec Time = 240 sec University of Illinois Chicago, LPPD, Summer 2011

  5. Agarose Gel Experimental Design Petri dish ? 0.5 % Agarose gel Syringe loaded with magnetite nanoparticles 173 lb pull force magnet Control University of Illinois Chicago, LPPD, Summer 2011

  6. Agarose Gel Early Results Control 35 lb pull force 173 lb pull force Syringe line Base of petri dish Magnetic nanoparticles were guided toward the magnets through 0.5% agarose gel University of Illinois Chicago, LPPD, Summer 2011

  7. Rat Brain Experiments Determining permeability of Prussian blue stain on unfixed rat brain Rat brain in Prussian blue stain Coronal cross section with no staining Rat brain in saline solution Set up for magnetic nanoparticle movement on unfixed rat brain 173 lb pull force magnet and a control Coronal cross section of rat brain Adding 10 µl magnetite nanoparticles University of Illinois Chicago, LPPD, Summer 2011

  8. Future Work • Continue with magnetic nanoparticle experiments to reduce agglomeration of nanoparticles and allow for convection enhanced delivery. • Determine the most effective protocol for administrating and measuring magnetically-guided nanoparticles in rat brain samples. • Investigate methods of manufacturing nanoparticles for better visualization in angiogram – possible gold plated magnetite. University of Illinois Chicago, LPPD, Summer 2011

  9. Acknowledgements • NSF EEC-0502272 Grant, Chicago Science Teacher Research • Dr. Andreas Linninger • Members of the LPPD – Eric Lueshen, SukhiBasati, Joe Kanikunnel University of Illinois Chicago, LPPD, Summer 2011

More Related