1 / 9

Thrombin

Thrombin. Suman Kasoji Sahill Patel Daniel Wang Jacawb Panicker. Gland. Prothrombin, a prerequisite to creating thrombin, is secreted from the liver. Furthermore, thrombin is produced by the cleavage of two prothrombin sites by activated Factor X.

jeroen
Download Presentation

Thrombin

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Thrombin SumanKasoji Sahill Patel Daniel Wang JacawbPanicker

  2. Gland • Prothrombin, a prerequisite to creating thrombin, is secreted from the liver. • Furthermore, thrombin is produced by the cleavage of two prothrombin sites by activated Factor X. • Thrombin itself is not secreted by a gland, therefore it does not have a large role in the endocrine system.

  3. Peptide-based Thrombin • Thrombin is a multifunctional serine protease that has many regenerative and repairing functions throughout the body • Blood clotting • Inflammation • Tumor metastasis

  4. Pathway • In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, and fibrinogen to fibrin.

  5. Cellular Response • Thrombin has many biological functions in the body, most notable its coagulator tasks. • In regard to cellular response, thrombin is known for activating endothelial and immune cells. • The coagulation protease thrombin triggers fibrin formation and platelet activation.

  6. Positive Feedback • Thrombin is a vital enzyme in the activation of factors VIII and V, which are critical to blood clotting functions. • Thrombin’s three positive feedback effects: • The activation of platelets • Activation of factor VIII • Activation of factor V

  7. Negative Feedback • Negative Feedback: thrombin activates protein C, which is an inhibitor of the coagulation cascade • Activating protein C is enhanced after the binding of thrombin to thrombomodulin, which is an fundamental membrane protein expressed by endothelial cells. • Thrombin is inactivated by antithrombin, a serine protease inhibitor.

  8. Signaling Pathway Interference • Hemophilia, a disease in which blood is unable to clot, has an effect on the signal pathway of thrombin. • Thrombin converts factor VIII to VIIIa, but in hemophilia, factor VIII is deficient, thus there is nothing for thrombin to convert.

  9. Works Cited • http://serpins.med.unc.edu/~fcc/ResearchPicts2006/Thrombin.html • http://arno.unimaas.nl/show.cgi?fid=13259 • http://www.qiagen.com/products/genes%20and%20pathways/Pathway%20Details.aspx?pwid=434

More Related