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Professor of Experimental Psychology Department of Psychology. Veena Kumari. PSYCHOSIS Improving Treatment Outcome. Biological and behavioural changes following psychological and biological therapies Characteristics of schizophrenia patients who show insufficient response
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Professor of Experimental Psychology Department of Psychology Veena Kumari
PSYCHOSISImproving Treatment Outcome • Biological and behavioural changes following psychological and biological therapies • Characteristics of schizophrenia patients who show insufficient response • New / modified strategies for poor responders Recent Findings • CBTp reduces brain responses to social threat. • (Kumari et al., 2011, Brain) • CBTp non-responders have smaller hippocampus. • (Premkumar et al, 2009, Schiz Res) • Lower prefrontal activity predicts poor CBTp response. • (Kumari et al. 2009, Biological Psychiatry) • Enhanced frontal response with atypical antipsychotics. • (Ettinger et al., 2011, Psychopharmacology)
SEX, DRUGS & PSYCHOSIS Ovarian hormones and schizophrenia Ovarian hormones and response to antipsychotics Recent Findings • Sex differences in prepulse inhibition of the startle • response in healthy young, but not older samples • (Kumari, 2011 Curr. Top. Behav. Neurosci.; Kumari et al., 2008, Psychoneuropharmacology ) • Antipsychotic-like effect of progesterone in this model • (Kumari et al., 2010, Psychoneuropharmacology)
Brain abnormalities and violent behaviour in SZ and APD Psychobiological abnormalities and treatment outcome in mentally disordered offenders New / modified treatment strategies for poor outcome offenders VIOLENCE IN MENTAL DISORDERSNeurobiology and Treatment Outcome Recent Findings • Opposite pattern of neural and behavioural response to anticipated threat in SZ and APD (Kumari et al., 2009, Schiz Res) • Differential cognitive and neural deficits in SZ and APD • (e.g. Barkataki et al., 2008, Behav Sci Law; Narayan et al., 2007, Am J Psychiatry)