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NADH:FMN- oxidoreductase

NADH:FMN- oxidoreductase. from Vibrio Fischeri Выполнила Кириллова Мария ФБ0801с. http://www.rcsb.org/pdb/explore/explore.do?structureId=1VFR. Aliivibrio fischeri. Bacteria; Proteobacteria ; Gammaproteobacteria ; Vibrionales ; Vibrionaceae ; Aliivibrio .

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NADH:FMN- oxidoreductase

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  1. NADH:FMN-oxidoreductase from VibrioFischeri Выполнила Кириллова Мария ФБ0801с http://www.rcsb.org/pdb/explore/explore.do?structureId=1VFR

  2. Aliivibriofischeri • Bacteria; • Proteobacteria; • Gammaproteobacteria; • Vibrionales; • Vibrionaceae; • Aliivibrio.

  3. NADH:FMN-оксидоредуктаза катализирует реакцию: NADH + FMN → NAD+ FMNH2 • Является гомодимером, и каждый мономер связывается с FMN как с кофактором • EC 1.6.8.1

  4. NADPH FMN NADP+ FMNH2

  5. http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=9643http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=9643

  6. NAD(P)H\:FMN OXIDOREDUCTASE flavin mononucleotide http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=9643

  7. 217 аминокислотных остатков: • 48% спирали (14 спиралей; 106 остатков) • 16% β-листов(8 нитей; 35 остатков) http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=1VFR&params.annotationsStr=DSSP%2CSCOP&params.showJmol=false

  8. FMN http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=444243 http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=444243

  9. FMN Computed Properties: • Molecular Formula C17H21N4O9P+ • Molecular Weight 457.351741 [g/mol] • H-Bond Donor 7 • H-Bond Acceptor 10 • Heavy Atom Count 31 • Formal Charge 1 • Covalently-Bonded Unit Count 1

  10. http://www.rcsb.org/pdb/explore/explore.do?structureId=1VFR

  11. NADPH http://www.brenda-enzymes.org/Mol/Mol.php4?n=14331 http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5886

  12. NADPH • Computed Properties: • Molecular Weight 744.412943 [g/mol] • Molecular Formula C21H29N7O17P3+ • H-Bond Donor 9 • H-Bond Acceptor 17 • Heavy Atom Count 48 • Formal Charge 1 • Covalently-Bonded Unit Count 1

  13. Где изучают • Houston • ‍ Tokyo • ‍ Yokohama • ‍ Kyoto • ‍ Shizuoka, Japan • ‍ Krasnoyarsk • ‍ Moscow, Russia • ‍ Zhongxing • ‍ Athens, USA • ‍ London • ‍ Turku • ‍ College Station • ‍ Япония • США • Россия • Китай • Великобритания • Финляндия

  14. http://gopubmed.org/web/gopubmed/1?WEB01418s2w7gmm65IiIxI0

  15. Кто изучает • Zenno S • ‍ Saigo K • ‍ Tu S • ‍ Tanokura M • ‍ Inouye S • ‍ Lei B • ‍ Jeffers C • ‍ Koike H • ‍ Sasaki H • ‍ Koike H • ‍ Hirayama S • ‍ Karatani H • ‍ Izuta T • ‍ Maruhashi K • ‍ Ishii Y • ‍ Konishi J • ‍ Suzuki M • ‍ Van Hoek A • ‍ Vetrova E • ‍ Kudryasheva N • Visser A • ‍ Wang H • ‍ Yu Y • ‍ Tang C • ‍ Nichols J • ‍ Danilov V • ‍ Mazhul' M • ‍ Zavil'gel'skiĭ G • ‍ Zarubina A • ‍ Iudina • ‍ Nohmi T • ‍ Watanabe M • ‍ Nishino T • ‍ Takio K • ‍ Sofuni T • ‍ Kobori T • ‍ Murphy M • ‍ Adman E • ‍ Weng S • Lin J • Chao Y • ‍ Lee J • ‍ Petushkov V • ‍ Li W • ‍ Parry R • ‍ Nakamura H • ‍ Kanoh H • ‍ Rabin B • ‍ Harbron S • ‍ Eggelte H • ‍ Benson S • ‍ Ståhlberg T • ‍ Lavi J • ‍ Raunio R • ‍ Baldwin T • ‍ Daubner S • ‍ Astorga A • ‍ Leisman G • ‍ Hjertén S • ‍ BrolinS • DeLuca M • ‍ Jablonski E

  16. Где об этом пишут • Biochemistry-us • ‍ J Bacteriol • ‍ PhotochPhotobioSci • ‍ Arch BiochemBiophys • ‍ BiochemBioph Res Co • ‍ J BioluminChemilumin • ‍ J BiosciBioeng • ‍ Luminescence • ‍ Mikrobiologiia • ‍ J BiolChem • ‍ J Mol Biol • ‍ Eur J Biochem • ‍ J Biochem • ‍ J StructBiol • ‍ FebsLett • ‍ P NatlAcadSciUsa • ‍ Mol Cell Biochem

  17. Используемые базы данных • http://www.rcsb.org/pdb • http://www.ncbi.nlm.nih.gov/pubmed • http://www.gopubmed.org

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