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The Nanomedicine Delivery Challenge

The Nanomedicine Delivery Challenge. You have learned that some sunscreen products contain nanoscale structures . Nanoscale structures in sunscreen include clusters of zinc oxide and/or titanium oxide. Different number of ions can cluster together.

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The Nanomedicine Delivery Challenge

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  1. The Nanomedicine Delivery Challenge

  2. You have learned that some sunscreen products contain nanoscale structures.

  3. Nanoscale structures in sunscreen include clusters of zinc oxide and/or titanium oxide Different number of ions can cluster together. • ZnO always has equal numbers of Zn and O ions • TiO2 always has twice as many O ions as Ti ions ~100 nm TiO2 particle ~200 nm TiO2 particle Source: Images adapted from http://www.cse.clrc.ac.uk/msi/projects/ropa.shtml

  4. The unbalanced chemical equation below describes the formation of iron oxide structures commonly called magnetite. FeCl3 + FeCl2 + NH4+ + OH−→ Fe3O4 + NH4Cl Water is used to rinse off the ammonium chloride.

  5. A surfactant is then mixed with the iron oxide so that nanoscale clusters of iron oxide form.

  6. The magnetite clusters can be put into a demonstration cell that contains an organic liquid. The clusters can be manipulated in a magnetic field and behave like a fluid.

  7. Ferrofluids as a model of a nanoscale medicine The goal for your group is to use the materials in the plastic containers to propose methods for delivering a nanoscale medicine to a specific location in the human body. The activity has been adapted from the November 2006 Science Scope Journal article “Nanomedicine: Problem Solving to Treat Cancer” co-authored by Melissa A. Hemling, Lauren M Samuel, Greta Zenner, Amy C. Payne, and Wendy C. Crone.

  8. There are Three Data Tables • In Data Table #1 you need to describe the effectiveness of medicine delivery devices. • In Data Table #2 you need to compare the behaviors of nanoscale and larger than nanoscale particles in a magnetic field. • In Data Table #3 you need to describe the possible advantages and disadvantages of a medicine that responds to a magnetic field.

  9. Credits Slide 1: A manipulated nanoscale structure: Nanomedicine: Problem solving to treat cancer by Melissa A. Hemling, Lauren M. Samuel, Greta Zenner, Amy C. Payne, and Wendy C. Cron Science Scope Journal; November 2006 Slide 5 : FerroFluid Structure; Page 944Journal of Chemical Education • Vol. 76 No. 7 July 1999 • JChemEd.chem.wisc.edu Slide 6: A FerroFluid display cell available from Educational Innovations Inc . At: http://www.teachersource.com/ElectricityAndMagnetism/Ferrofluid/FerrofluidPreformDisplayCell.aspx YouTube video at: http://www.youtube.com/watch?v=9SKVHv63SlM&feature=related

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