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Thomas Hoy Department of Biomedical Engineering BME 273 Senior Design January 30, 2004

Ostium Secundum Atrial. Septal Defect Closure. Thomas Hoy Department of Biomedical Engineering BME 273 Senior Design January 30, 2004 . Project Definition. What is a Ostium Secundum Atrial Septal Defect? congenital heart disease causes left to right shunting across interatrial septum

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Thomas Hoy Department of Biomedical Engineering BME 273 Senior Design January 30, 2004

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  1. Ostium Secundum Atrial Septal Defect Closure Thomas Hoy Department of Biomedical Engineering BME 273 Senior Design January 30, 2004

  2. Project Definition • What is a Ostium Secundum Atrial Septal Defect? • congenital heart disease • causes left to right shunting across interatrial septum • Why should we care? • Isolated secundum atrial septal defects of significance occur in approximately 70,000-100,000 individuals today. • Isolated ASDs can cause congestive heart failure or Eisenmengers syndrome

  3. Goals • To develop a less costly occlusion device for an ASD. • To develop an occlusion device that is easily sized to the ASD. • To ensure easy use of this device in medicine.

  4. Further Goals • To design a device that should: • Provide more accurate application • Less strain on the applied interatrial wall • Stimulate endotheliazation of the device • Be lower in cost and more simplistic in design • Improve the quality of life of the patient

  5. Common Occlusion Devices • Amplatzer – most widely used • HELEX Device • Das Angel Wings • ASDOS • STARFlex Occluder • Sideris "Buttoned Device"

  6. Amplatzer Occlusion Device • Research • Study of engineering aspects of the Amplatzer design • Study of how devices fit into catheters and how they work. • Brainstorming possible solutions to these problem

  7. Amplatzer Deployment • Patient is sedated • Dynamic X-ray device used with dye to place the device • Conformation through trans-esophageal echocardiogram

  8. Amplatzer Detachment • Locking mechanism screws into place • Device is unscrewed from catheter • Amplatzer is able to be recaptured if a problem were to arise.

  9. Before and After

  10. Future Work • Scheduled another meeting with advisor to discuss progress • Continued brainstorming and documentation of possible designs and implementation devices • Study engineering possibilities of designs and modeling for catheter deployment • Model

  11. Works Cited • Moodie DS, Sterba, R. Long-term outcomes excellent for atrial septal defect repair in adults. Cleveland Journal of Medicine 2000; 67(8):591-597. • Hughes ML, Maskell G, Goh TH, Wilkinson JL. Prospective comparison of costs and short term health outcomes of surgical versus device closure of atrial septal defect in children. Heart 2002; 88:67-70. • Thomson JDR, Aburawi EH, Watterson KG, Van Doorn C, Gibbs JL. Surgical and transcatheter (Amplatzer) closure of atrial septal defects: A prospective comparison of results and cost. Heart 2002; 87:466-469. • AGA Medical Corporation, http://www.amplatzer.com/products/aso_imp_demo.html

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