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Activation 0f S-phase genes(Cycle E, A, E2Fs, DHFR,TK,TS,POL,CDK1)

Active (E2F). Activation 0f S-phase genes(Cycle E, A, E2Fs, DHFR,TK,TS,POL,CDK1). Strategies for signalling inhibition. Immune effector cell. Anti-ligand mAbs. Bispecific Abs. scFv/toxin conjugates. Ligand/toxin conjugate. Ligand- genistein conjugates. Anti-receptor mAbs.

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Activation 0f S-phase genes(Cycle E, A, E2Fs, DHFR,TK,TS,POL,CDK1)

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  1. Active (E2F) Activation 0f S-phase genes(Cycle E, A, E2Fs, DHFR,TK,TS,POL,CDK1)

  2. Strategies for signalling inhibition Immuneeffector cell Anti-ligand mAbs BispecificAbs scFv/toxinconjugates Ligand/toxin conjugate Ligand- genisteinconjugates Anti-receptormAbs Inhibitors of other signalling molecules Nucleus IntracellularscFvs Tyrosine kinase inhibitors (TKIs) Antisense

  3. Mode of action of EGFR inhibitors EGF/TGFα R R Antibody Extracellular Membrane û û Intracellular EGFR-TKI EGFR-TKI K K û Cell survival (anti-apoptosis) Proliferation Signalling DNA Growth factors Angiogenesis Chemotherapy/ radiotherapy sensitivity Metastasis R, epidermal growth factor receptor

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