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Ubiquitin mediated proteolysis

x. G1. S. G2. M. Cell Cycle. NO. p21 (Waf1/Cip1). APC/C CDC20. p38 MAPK. CDC25B. - p. CCNA CDK2. CCNA CDK1. CCNE CDK2. + p. Ubiquitin mediated proteolysis. CCNB CDK1. CCND CDK4,6. + p. + p. + p. + p. PLK. CDC6. Rb. ORC. Rb. E2F1 DP1. APC/C Cdh1.

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Ubiquitin mediated proteolysis

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  1. x G1 S G2 M Cell Cycle NO. p21 (Waf1/Cip1) APC/C CDC20 p38 MAPK CDC25B - p CCNA CDK2 CCNA CDK1 CCNE CDK2 + p Ubiquitin mediated proteolysis CCNB CDK1 CCND CDK4,6 + p + p + p + p PLK CDC6 Rb ORC Rb E2F1DP1 APC/C Cdh1 DNA biosynthesis DNA DNA S-phase proteins Activation Inhibition

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