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Human Rrp6 protein represses HIV transcription

Human Rrp6 protein represses HIV transcription. Emilie Rousset, Alexandre Wagschal, Poornima Basavarajaiah, Daniel Latreille, Christine Chable-Bessia, Xavier Contreras , Yamina Bennasser and Rosemary E. Kiernan

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Human Rrp6 protein represses HIV transcription

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  1. Human Rrp6 protein represses HIV transcription Emilie Rousset, Alexandre Wagschal, Poornima Basavarajaiah, Daniel Latreille, Christine Chable-Bessia, Xavier Contreras, Yamina Bennasser and Rosemary E. Kiernan Laboratoire régulation des gènes, Institut de Génétique Humaine (IGH), Montpellier, France Poster WEPDA104 MTR4 C1D 5 9 8 3 Nuclear Coreexosome 1 4 6 2 • Rrp6 = RNA quality control • 3’-5’ exoribonuclease • Rrp6 catalytic subunit of the exosome • C1D (nucleic acid fixation) and MTR4 (RNA helicase) modulate its catalytic activity 7 Rrp6 RNA 3’ 5’

  2. Rrp6 represses HIV-LTR driven transcription TAR Integrated Promoter-proximal HIV promoter Luciferase 120 7mG RNAPII (total) 100 3’ 5’ LUCIFERASE 80 Fold increase 60 40 20 120 0 Rrp6 100 SiRNA: Scr 80 Fold activation 60 40 20 0 Rrp6 (30) siRNA: Scr

  3. Working model C1D 5-FU 5 9 8 MTR4 3 1 4 6 2 ? 7 Rrp6 Nuclear Exosome G9a 1 2 BIX TAR H3K9Me2 +1 RNA pol II HIV-LTR

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