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GABA Mediates Responses in Co-cultures of Rat Carotid Body and Petrosal Neurons Min Zhang Department of Biology, McMaster University, Hamilton, Ontario, Canada. type 1. PN. Postsynaptic action of BABA via GABAa receptors. Presynaptic action of GABA via GABAb recepors. Summary

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  1. GABA Mediates Responses in Co-cultures of Rat Carotid Body and Petrosal NeuronsMin ZhangDepartment of Biology, McMaster University, Hamilton, Ontario, Canada

  2. type 1 PN

  3. Postsynaptic action of BABA via GABAa receptors

  4. Presynaptic action of GABA via GABAbrecepors

  5. Summary • GABA is expressed in carotid body chemoreceptor type 1 cells. • GABA released from the CB during hypoxia, inhibits sensory discharge postsynaptically via a shunting mechanism involving GABAa receptors. • GABAb receptor-mediated activation of TASK-1 or related channel provides a presynapticautoregulatory feedback mechanism that modulates fast synaptic transmission in rat carotid body.

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