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Striatal intrinsic plasticity and information processing in the corticostriatal funnel

Striatal intrinsic plasticity and information processing in the corticostriatal funnel. Cortical synchronization. Firing of striatal medium spiny neurons. +. Short-term intrinsic plasticity. Cortical requirements for striatal MS neuron firing. Cerebral cortex. Striatum.

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Striatal intrinsic plasticity and information processing in the corticostriatal funnel

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  1. Striatal intrinsic plasticity and information processing in the corticostriatal funnel

  2. Cortical synchronization Firing of striatal medium spiny neurons + Short-term intrinsic plasticity

  3. Cortical requirements for striatal MS neuron firing Cerebral cortex Striatum Intrinsic plasticity

  4. Membrane constants of MS neurons are not constant Vm From Charlie Wilson

  5. Experimental demonstration of a need of cortical spatio-temporal synchrony Desynchronized Synchronized

  6. Temporal and spatial contraction in the CS pathway

  7. Cortical synchronization as a trigger for striatal intrinsic plasticity?

  8. Spike-dependent increase in membrane excitability A C B D

  9. Spike-dependent facilitation of cortical inputs

  10. Effects on the corticostriatal input-output relationship No change in synaptic strength Decrease in spike threshold and latency

  11. Role of the striatal K+ current IAS In vitro experiments Properties of IAS Activation of outward K+ current (IAs) Slow recovery from inactivation (t ~ 300 ms)

  12. Striatal intrinsic plasticity: Changes in the cortical parameters effective for striatal neurons firing and optimization of the information transfer in the corticostriatal pathway Intrinsic plasticity

  13. Séverine Mahon (University College of London) Stéphane Charpier (INSERM U667 Collège de France) Guilaume Casassus (UMR CNRS 5091Institut François Magendie) Christophe Mulle (UMR CNRS 5091Institut François Magendie)

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