1 / 2

OUT

OUT. OUT. OUT. OUT. IN. IN. N. N. C. C. rClaudin-2 136-230. rClaudin-4 136-209. IN. IN. N. N. C. C. Claudin-4. Claudin-2. OUT. OUT. OUT. OUT. IN. IN. N. N. C. C. rClaudin-2 108-230. rClaudin-4 108-209. IN. IN. N. N. C. C.

mara-leach
Download Presentation

OUT

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. OUT OUT OUT OUT IN IN N N C C rClaudin-2136-230 rClaudin-4136-209 IN IN N N C C Claudin-4 Claudin-2 OUT OUT OUT OUT IN IN N N C C rClaudin-2108-230 rClaudin-4108-209 IN IN N N C C Claudin-4 chimera second extracellular loop claudin-4/E2 Claudin-2 chimera second extracellular loop claudin-2/E4 OUT OUT IN IN N N C C Claudin-2 Claudin-4 A B

  2. C Claudin-1D150N N S N D S N D N C Supplemental Fig. 1. Diagrams of claudins, chimeric claudins, claudin C-terminal fragments, and claudin mutants used in this study. (A) Predicted structure of the claudin components of recombinant claudin species used in Fig. 2 experiments. (B) Predicted structure of claudin chimera constructs used in Fig. 2 and 3, noting the change in the ECL-2 of Claudin-2/E4 and Claudin-4/E2. (C) Representation of claudin ECL-2 point mutations, with amino acid change indicated, that were used as soluble rClaudins in Fig. 5 experiments or were stably expressed by Rat1-R12 fibroblast transfectants in Fig. 6 studies. OUT OUT IN N N C Claudin-4N149D C C Claudin-4N149S OUT OUT IN N N Claudin-2S149N

More Related