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Sham

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Sham

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  1. Figure S1: T-cell deficient mice lose more trabecular bone than T-cell sufficient mice: 8 week old mice deficient in αβ T-cells (TCRα-/-), only CD8 T-cells (β2M-/-) or sufficient in T-cells (WT = C57BL/6J) were treated with 1 mg/kg RANKL (+RANKL; administered intraperitoneally twice 24 hours apart) relative to PBS-treated mice (-RANKL). Tibias were harvested andarea (30 slices) starting at the proximal growth plate analyzed by μCT. BV/TV and representative images areshown in Fig. 1B; here we show the trabecular bone parameters, trabecular number (Tb.N), thickness (Tb.Th), spacing (Tb.Sp) and bone mineral density (BMD) for all four groups.

  2. Figure S2: Adoptive transfer of polyclonal OC-iTcREG protects OT-I mouse from trabecular bone loss: μCT of distal femur of OT-I mice which received OC-iTcREG showed higher trabecular thickness (Tb.Th), lower trabecular number (Tb.N), and showed no difference in trabecular spacing (Tb.Sp) compared to control mice.

  3. Sham OVX OC-iTcREG Sham OVX OC-iTcREG Figure S3: Adoptive transfer of polyclonal OC-iTcREG limits bone loss in ovariectomized mice: μCT of proximal tibia of sham or ovariectomized (OVX) mice untreated, treated with OC-iTcREG, CD3 CD28 activated CD8 T-cells, or Zoledronate. Ten days later OVX mice treated with OC-iTcREG showed increased bone mineral density, no difference in trabecular number (Tb.N), no difference in trabecular spacing (Tb.Sp), and an increase in trabecular thickness (Tb.Th) compared to untreated controls.

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