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Genes and Function: The Rewriting of our <br />Textbooks of Pathology

Genes and Function: The Rewriting of our <br />Textbooks of Pathology. Presented By David Hafler at 2014 ASCO Annual Meeting. Slide 2. Presented By David Hafler at 2014 ASCO Annual Meeting. Slide 3. Presented By David Hafler at 2014 ASCO Annual Meeting. Slide 4.

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Genes and Function: The Rewriting of our <br />Textbooks of Pathology

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  1. Genes and Function: The Rewriting of our <br />Textbooks of Pathology Presented By David Hafler at 2014 ASCO Annual Meeting

  2. Slide 2 Presented By David Hafler at 2014 ASCO Annual Meeting

  3. Slide 3 Presented By David Hafler at 2014 ASCO Annual Meeting

  4. Slide 4 Presented By David Hafler at 2014 ASCO Annual Meeting

  5. Slide 5 Presented By David Hafler at 2014 ASCO Annual Meeting

  6. Slide 6 Presented By David Hafler at 2014 ASCO Annual Meeting

  7. Slide 7 Presented By David Hafler at 2014 ASCO Annual Meeting

  8. Slide 8 Presented By David Hafler at 2014 ASCO Annual Meeting

  9. Slide 9 Presented By David Hafler at 2014 ASCO Annual Meeting

  10. Slide 10 Presented By David Hafler at 2014 ASCO Annual Meeting

  11. Slide 11 Presented By David Hafler at 2014 ASCO Annual Meeting

  12. Slide 12 Presented By David Hafler at 2014 ASCO Annual Meeting

  13. Slide 13 Presented By David Hafler at 2014 ASCO Annual Meeting

  14. Slide 14 Presented By David Hafler at 2014 ASCO Annual Meeting

  15. Slide 15 Presented By David Hafler at 2014 ASCO Annual Meeting

  16. Glioblastoma multiforme Presented By David Hafler at 2014 ASCO Annual Meeting

  17. Treatments Presented By David Hafler at 2014 ASCO Annual Meeting

  18. WHO Classification Presented By David Hafler at 2014 ASCO Annual Meeting

  19. Slide 19 Presented By David Hafler at 2014 ASCO Annual Meeting

  20. Slide 20 Presented By David Hafler at 2014 ASCO Annual Meeting

  21. PD-1 Expression CD4 T effectors in on Glioblastoma Presented By David Hafler at 2014 ASCO Annual Meeting

  22. Slide 22 Presented By David Hafler at 2014 ASCO Annual Meeting

  23. Slide 23 Presented By David Hafler at 2014 ASCO Annual Meeting

  24. Slide 24 Presented By David Hafler at 2014 ASCO Annual Meeting

  25. Slide 25 Presented By David Hafler at 2014 ASCO Annual Meeting

  26. Patient survival linked to Tumor-associated Tregs Presented By David Hafler at 2014 ASCO Annual Meeting

  27. Increase numbers of regulatory T Cells in Glioblastoma Presented By David Hafler at 2014 ASCO Annual Meeting

  28. Tregs and CD4 T effector cells in glioblastoma are Tim3+PD-1+ Presented By David Hafler at 2014 ASCO Annual Meeting

  29. Slide 29 Presented By David Hafler at 2014 ASCO Annual Meeting

  30. PD-1+Tim3+ Tregs restricted to grade 4 glioblastoma Presented By David Hafler at 2014 ASCO Annual Meeting

  31. Absence of Tim3+PD-1+ Tregs in the blood of healthy controls Presented By David Hafler at 2014 ASCO Annual Meeting

  32. Slide 32 Presented By David Hafler at 2014 ASCO Annual Meeting

  33. Slide 33 Presented By David Hafler at 2014 ASCO Annual Meeting

  34. Slide 34 Presented By David Hafler at 2014 ASCO Annual Meeting

  35. Slide 35 Presented By David Hafler at 2014 ASCO Annual Meeting

  36. Blocking monoclonal antibodies increase CD4 T effector proliferation but not Treg suppression Presented By David Hafler at 2014 ASCO Annual Meeting

  37. Slide 37 Presented By David Hafler at 2014 ASCO Annual Meeting

  38. Impaired suppression by GBM-Treg and proliferative response by GBM-Teff Presented By David Hafler at 2014 ASCO Annual Meeting

  39. PD-1+Tim3+ Tregs have decreased suppressor function Presented By David Hafler at 2014 ASCO Annual Meeting

  40. PD-1+ CD4 effector cells and Tregs have shortened telomeres Presented By David Hafler at 2014 ASCO Annual Meeting

  41. Slide 41 Presented By David Hafler at 2014 ASCO Annual Meeting

  42. Slide 42 Presented By David Hafler at 2014 ASCO Annual Meeting

  43. Slide 43 Presented By David Hafler at 2014 ASCO Annual Meeting

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