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Biochemistry of Coagulation

Biochemistry of Coagulation. Ahmad Shihada Silmi Msc, FIBMS Staff Specialist in Hematology Medical Technology Department Islamic University of Gaza 2012. The Protein C Anticoagulant Pathway. Blood Flow. Protein C. Thrombin. Thrombin. APC. Thrombomodulin. Thrombus.

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Biochemistry of Coagulation

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  1. Biochemistry of Coagulation Ahmad Shihada Silmi Msc, FIBMS Staff Specialist in Hematology Medical Technology Department Islamic University of Gaza 2012

  2. The Protein C Anticoagulant Pathway Blood Flow Protein C Thrombin Thrombin APC Thrombomodulin Thrombus Anticoagulation downstream Thrombusat site of injury

  3. The Protein C Anticoagulant Pathway Blood Flow Vai Factor V Leiden VIIIai VIIIa APC PS APC Va PS Thrombus

  4. AT III Th H AT III Proposed Mechanism of AT III-Heparin System Lysine sites H Serine site Arginine site Heparin Thrombin Antithrombin III Th

  5. Fibrinolytic Pathway Fibrinolysis is initiated when fibrin is formed and eventually dissolves the clot.

  6. Fibrinolytic Pathway PAI-1 Plasminogen Tissue Plasminogen Activator (t-PA) Urokinase (uPA) Exogenous: streptokinase Plasmin Inhibitor XL-Fibrin, fibrinogen Plasmin XL- fibrin degradation products (FDP)

  7. Fibrinogen or Fibrin Fragment X Small Peptides Fragment Y Fragment D Small Peptides Fragment E Fragment D Small Peptides Degradation of Fibrin/Fibrinogen Plasmin Plasmin Plasmin

  8. Approach to evaluate Fibrinolysis D-Dimer, a measure of fibrin degradation products, is the final product formed during the fibrinolysis process by plasmin

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