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EDCI / HOBt

O. O. O. O. O. HO. O. O. N. S. O. H. N. S. S. O. N. N. S. S. H. O. O. H. N. N. S. S. 1. N. H 2. H. O. 2. O. EDCI / HOBt. 30% TFA / DCM. O. O. O. H. HO. N. S. S. N. H. S. polyethylenimine. PEG. H 2 N. NH 2. DCC / DMAP. H. H. H. H. N. N. N.

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EDCI / HOBt

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  1. O O O O O HO O O N S O H N S S O N N S S H O O H N N S S 1 N H2 H O 2 O EDCI / HOBt 30% TFA / DCM O O O H HO N S S N H S polyethylenimine PEG H2N NH2 DCC / DMAP H H H H N N N N N NH 2 NH pre-formed, pos. charged polycation-DNA-complex HN N O N N O NH N N N S S N N H H H N HN H N 2 + O 3 HN NH O nucleic acid O + O Copolymer-Protectedgene vector (COPROG) O n n NH m HN Tyr Glu Glu Glu Glu Glu O H Lys- -ahx- Cys e N S peptide YE5C + + + + + + + + + S Tyr Glu Glu Glu Glu Glu O O m HN neg. charged peptide-PEG copolymer Supplementary Figure 1

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