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A new dawn

A new dawn. Genomewide association studies (GWAS). Genome-wide scan for seven diseases. P<1x10 -5 Green. WTCCC, Nature 7 June 2007. Genome-wide association scan. 2,000 individuals for each of the 7 major diseases 3000 shared controls

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A new dawn

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  1. A new dawn Genomewide association studies (GWAS)

  2. Genome-wide scan for seven diseases P<1x10-5 Green WTCCC, Nature 7 June 2007

  3. Genome-wide association scan • 2,000 individuals for each of the 7 major diseases • 3000 shared controls • 24 independent association signals identified at p<5x10-7 • Across all diseases-58 loci • (6 for HT) with p values between 10-5and 5 x10-7

  4. Association of SNPs with coronary artery disease or myocardial infarction Cyclin dependent kinase inhibitors 2A & 2B Replication Samani et al, NEJM 2007;357:443

  5. Guilt by association- WTCCC In a tour-de-force demonstration of feasibility, a consortium of 50 research teams used 500,000 genetic markers from each of 17,000 individuals to identify 24 genetic risk factors for 7 common human diseases Nature, 7 June 2007 Wellcome Trust Case Control Consortium

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