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A-Lipoic Acid Effects on Painful Diabetic Neuropathy Symptoms and Quality of Life

Investigating the impact of 600mg/day a-lipoic acid on symptoms, quality of life, and health status in patients with painful diabetic neuropathy over 40 days, showcasing reductions in neuropathic symptoms and improving patients' quality of life.

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A-Lipoic Acid Effects on Painful Diabetic Neuropathy Symptoms and Quality of Life

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  1. Effect Of A-Lipoic Acid on Symptoms and Quality of Life in Patients with Painful Diabetic Neuropathy By EvangelosAgathos, Anastasios Tentolouris, IonnaEleftheriadou, PanagiotaKatsaouni, Christina Papanikolau & Nikolaos Tentolouris Powerpoint by Jemima Jennyl B. Baquiran, DMD

  2. Introduction

  3. Diabetes Characterized by chronic hyperglycemia that produces dysregulation of cellular metabolism.1 A major public health problem affecting 9% of adults worldwide. 1 out of 11 adults worldwide now have type 2 diabetes mellitus.2 Despite efforts to increase awareness of the disease and its risk factors, many remain undiagnosed.3 Peripheral neuropathy is a common complication in patients with diabetes.

  4. Diabetic Neuropathy The most common neuropathy in industrialized countries and it is associated with wide range of clinical manifestations.4 Associated with older age, long duration of diabetes mellitus, poor glycemic control, increased lipid levels and high blood pressure. In spite of prevalence, there is neither good prevention nor treatment for DPN.5

  5. A-lipoic Acid An essential co-enzyme for energy production in mitochondria and has an effect on whole-body physiology. Can be found in very low quantities in almost all foods, and is used as a dietary supplement and a pharmaceutical agent. Has been used as a dietary supplement at different doses in patients with diabetes mellitus type 2 due to its antioxidant, anti-inflammatory, and hypoglycemic effects. 6 Clinical studies investigating the effect of a-lipoic acid on diabetic neuropathy have revealed promising results in terms of neuropathic symptoms.

  6. Relevance

  7. DPN Linked with morbidity, increased mortality and impaired quality of life compared with patients who have diabetes but no neuropathy. Oxidative stress poses a significant role in the pathogenesis of DPN. ALA is a very potent oxidative agent, it has been shown to improve nerve blood flow, reduce oxidative stress and improve distal nerve conduction in a rat model of diabetic neuropathy agent.

  8. Objectives

  9. A-Lipoic Acid The study aims to investigate the effect of orally administered 600mg/day a-lipoic acid on symptoms, laboratory parameters, quality of life, and overall health status of patients with painful diabetic neuropathy over 40 days.

  10. Highlights

  11. A-Lipoic Acid Statistically significant reductions in neuropathic symptoms were noted by patients following the 40-day administration of a-lipoic acid, indicated by changes in questionnaires used such as Neuropathy Symptoms Score (NSS), Subjective Peripheral Neuropathy Screen (SPNSQ) and DouleurNeuropathique (DN4 ) scores.

  12. A-Lipoic Acid A 600 mg ALA over 40 days is found out that there is clinically significant and prompt reduction in neuropathy symptoms and an overall improvement in patients’ quality of life. Patients noted an overall improvement in quality of life, which was reflected by the reduction in pain severity and pain interference in terms of Brief Pain Inventory (BPI) scores. Included to this are the improvement in total score, burning spontaneous pain, pressing spontaneous pain, paroxysmal pain, evoked pain, and paresthesia/ dysesthesia in Neuropathic Pain Symptom Inventory (NPSI) scores; and work disability score, social life disability score, and family life disability score in the Sheehan Disability Scale (SDS).

  13. A-Lipoic Acid In terms to laboratory parameters, fasting triglyceride levels were significantly reduced during the ALA administration during the 40-day period. In addition, no statistically significant difference was found in terms of fasting glucose, total cholesterol, LDL-C, high-density lipoprotein cholesterol, HbA1c, BMI, arterial blood pressure or heart rate between the baseline and day 40 visits.

  14. Conclusion

  15. A-Lipoic Acid Administration of 600 mg/day ALA for 40 days, to patients with painful diabetic neuropathy, has a clinically significant impact on controlling neuropathy symptoms, fasting triglycerides, and quality of life. Half of the treated patients rated their health status as ‘much better’ or ‘very much better’ following 40 days of treatment. ALA may result to adverse reactions such as nausea, vomiting and mild skin reactions. It has yet to be determined if the improvement of neuropathy symptoms could be further enhanced if prolonged beyond 40 days and more importantly if this will have an impact on the long-term course of diabetic neuropathy.

  16. References 1 Diagnosis and Classification of Diabetes Mellitus. American Diabetes Association. 2013. 2 Zheng, Y., et al. Global Aetiology And Epidemiology of Type 2 Diabetes Mellitus and Its Complications. Nature Reviews Epidemiology. 2018. 3 Improving Outcomes in Patients with Diabetes Melllitus. Journal American Heart Association. 2019. 4 Said, G. Diabetic Neuropathy- A Review. Nature Clinical Practice Neurology. 2007. 5 Frank, T., et al. Structure-Function Relationships in Peripheral Nerve Contributions to Diabetic Neuropathy. PAIN. May 2019. 6 Nunez, V., Et Al. The Effect Of 600mg Alpha Lipoic Acid Supplementation on Oxidative Stress, Inflammation, And RAGE in Older Adults with Type 2 Diabetes Mellitus. Hindawi. 2019.

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