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Understanding Cell Communication Pathways - Signaling Mechanisms Unveiled

Explore the intricate world of cell communication pathways, from nerve cells showcasing local and long-distance signaling to the role of NGF as a water-soluble signal molecule. Discover the significance of protein kinases, phosphorylation cascades, and amplification mechanisms in cellular responses. Dive into the impact of scaffolding proteins on cell behavior in response to signaling molecules.

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Understanding Cell Communication Pathways - Signaling Mechanisms Unveiled

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  1. Chapter 11Cell Communication

  2. Chapter 11Cell Communication Concept Check Questions

  3. Chapter 11Cell Communication Explain how nerve cells provide examples of both local and long-distance signaling.

  4. Chapter 11Cell Communication Explain how nerve cells provide examples of both local and long-distance signaling. Synapse = local Electrical = long distance

  5. Chapter 11Cell Communication Nerve growth factor (NGF) is a water-soluble signal molecule. Would you expect the receptor for NGF to be intracellular or in the plasma membrane? Why?

  6. Chapter 11Cell Communication Nerve growth factor (NGF) is a water-soluble signal molecule. Would you expect the receptor for NGF to be intracellular or in the plasma membrane? Why? Hydrophylic

  7. Chapter 11Cell Communication What is a protein kinase, and what is its role in a signal transduction pathway?

  8. Chapter 11Cell Communication What is a protein kinase, and what is its role in a signal transduction pathway? A protein that phosphorylates another protein, often in a cascade.

  9. Chapter 11Cell Communication When a signal transduction pathway involves a phosphorylation cascade, how does the cell’s response get turned off?

  10. Chapter 11Cell Communication Protein kinase = on Protein phosphatase = off

  11. Chapter 11Cell Communication Upon activation of phospholipase C by ligand binding to a receptor, what effect does the IP3-gated calcium channel have on Ca2+ concentration in the cytosol?

  12. Chapter 11Cell Communication Gate opens. Ca++ flows out of ER. [Ca++] goes up.

  13. Chapter 11Cell Communication How can a target cell’s response to a hormone be amplified more than a millionfold?

  14. Chapter 11Cell Communication How can a target cell’s response to a hormone be amplified more than a millionfold? cascade

  15. Chapter 11Cell Communication How can a target cell’s response to a hormone be amplified more than a millionfold? cascade

  16. Chapter 11Cell Communication How can a target cell’s response to a hormone be amplified more than a millionfold? cascade

  17. Chapter 11Cell Communication How can a target cell’s response to a hormone be amplified more than a millionfold? cascade

  18. Chapter 11Cell Communication How can a target cell’s response to a hormone be amplified more than a millionfold? cascade

  19. Chapter 11Cell Communication Explain how two cells with different scaffolding proteins could behave differently in response to the same signaling molecule.

  20. Chapter 11Cell Communication

  21. Chapter 11Cell Communication

  22. Chapter 11Cell Communication

  23. Chapter 11Cell Communication

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