1 / 8

Sarcoidosis & Vitamin D

Sarcoidosis & Vitamin D. Lindsey Janeiro. Vitamin D. Fat-soluble vitamin Hormone Sources: Dietary Supplements, Synthesized from the sun. Vitamin D Functions. Regulating blood calcium levels Maintaining bone health Assisting in cell differentiation Regulation of immune response.

rey
Download Presentation

Sarcoidosis & Vitamin D

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Sarcoidosis & Vitamin D Lindsey Janeiro

  2. Vitamin D • Fat-soluble vitamin • Hormone • Sources: • Dietary • Supplements, • Synthesized from the sun Thompson JL, Manore MM, Vaughan LA. The Science of Nutrition. Second Edition. San Francisco, CA: Pearson Higher Ed.; 2011.

  3. Vitamin D Functions • Regulating blood calcium levels • Maintaining bone health • Assisting in cell differentiation • Regulation of immune response Thompson JL, Manore MM, Vaughan LA. The Science of Nutrition. Second Edition. San Francisco, CA: Pearson Higher Ed.; 2011. Hewison M. Vitamin D and the immune system: New perspectives on an old theme. Endocrinology & Metabolism Clinics of North America. 2010; 39(2): 365-379.

  4. Sarcoidosis • Chronic systemic inflammatory disease • Granulomas • Tiny clusters of immune cells (macrophages) • Typically affects: • Lungs, lymphatic system, eyes, skin, joints, heart, liver, and brain • Exact genetic causation unclear • Potential infectious, environmental, & genetic factors Kavathia D, Buckley JD, Rao D, Rybicki B, Burke R. Elevated 1,25-dihydroxyvitamin D levels are associated with protracted treatment in sarcoidosis. Respiratory Medicine. 2010; 104: 564-570. Maver A, Medica I, Salobir B, Tercelj M, Peterlin B. Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients. Genetic and Molecular Research. 2010; 9(1): 58-68. Rosenbaum JT, Pasadhika S, Crouser ED, et al. Hypothesis: Sarcidosis is a STAT1-mediated disease. Clinical Immunology. 2009; 132: 174-183.

  5. Sarcoidosis • Symptoms are usually non-specific complaints: • Fatigue • Depression • “Asthma symptoms” (wheezing, coughing) • Muscle pain • Weakness • Arthritis • Reduced work capacity • Hypercalcemia Kavathia D, Buckley JD, Rao D, Rybicki B, Burke R. Elevated 1,25-dihydroxyvitamin D levels are associated with protracted treatment in sarcoidosis. Respiratory Medicine. 2010; 104: 564-570. Hinz A, Fleischer M, Brähler E, Wirtz H, Bosse-Henck A. Fatigue in patients with sarcoidosis, compared to the general population. General Hospital Psychiatry. 2011; 33: 462-468.

  6. Correlation between Vitamin D and Sarcoidosis • Elevated 1,25-dihydroxyvitamin D3 • Increased 1α-hydroxylase activity • Kidneys • Macrophages • Excess calcitriol and calcium don’t lead to the shutdown of 1α-hydroxylase in macrophages • Hypercalcemia Hewison M. Vitamin D and the immune system: New perspectives on an old theme. Endocrinology & Metabolism Clinics of North America. 2010; 39(2): 365-379. Borges MC, Martini LA, Rogero MM. Current perspectives on vitamin D, immune system, and chronic diseases. Nutrition. 2011; 27: 399-404.

  7. The Metabolism of Vitamin D in a Normal Renal Cell Compared to a Macrophage Cell in Sarcoidosis Patients Ackermann D. Hypercalcemia in sarcoidosis – case report, prevalence, pathophysiology, and therapeutic options. TherUmsch. 2007; 64(5): 281-286. Hewison M. Vitamin D and the immune system: New perspectives on an old theme. Endocrinology & Metabolism Clinics of North America. 2010; 39(2): 365-379. Conrado T, Miranda-Filho DB, Bandeira F. Vitamin D deficiency in HIV-infected individuals: One more risk factor for bone loss and cardiovascular disease. ArquivosBrasileiros de Endocrinologia & Metabologia. 2002; 54 (2). http://dx.doi.org/10.1590/S0004-27302010000200006

  8. References • 1.) Thompson JL, Manore MM, Vaughan LA. The Science of Nutrition. Second Edition. San Francisco, CA: Pearson Higher Ed.; 2011. • 2.) Erdal BS, Clymer BD, Yildiz VO, Julian MW, Crouser ED. Unexpectedly high prevalence of sarcoidosis in a representative U.S. metropolitan population. Respiratory Medicine. 2012; xx: 1-7 (article in press, available online 3/12/2012) • 3.) Kavathia D, Buckley JD, Rao D, Rybicki B, Burke R. Elevated 1,25-dihydroxyvitamin D levels are associated with protracted treatment in sarcoidosis. Respiratory Medicine. 2010; 104: 564-570. • 4.) Ackermann D. Hypercalcemia in sarcoidosis – case report, prevalence, pathophysiology, and therapeutic options. TherUmsch. 2007; 64(5): 281-286. • 5.) Hewison M. Vitamin D and the immune system: New perspectives on an old theme. Endocrinology & Metabolism Clinics of North America. 2010; 39(2): 365-379. • 6.) Rosenbaum JT, Pasadhika S, Crouser ED, et al. Hypothesis: Sarcidosis is a STAT1-mediated disease. Clinical Immunology. 2009; 132: 174-183. • 7.) Hinz A, Fleischer M, Brähler E, Wirtz H, Bosse-Henck A. Fatigue in patients with sarcoidosis, compared to the general population. General Hospital Psychiatry. 2011; 33: 462-468. • 8.) Maver A, Medica I, Salobir B, Tercelj M, Peterlin B. Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients. Genetic and Molecular Research. 2010; 9(1): 58-68. • 9.) Borges MC, Martini LA, Rogero MM. Current perspectives on vitamin D, immune system, and chronic diseases. Nutrition. 2011; 27: 399-404. • 10.) Conrado T, Miranda-Filho DB, Bandeira F. Vitamin D deficiency in HIV-infected individuals: One more risk factor for bone loss and cardiovascular disease. ArquivosBrasileiros de Endocrinologia & Metabologia. 2002; 54 (2). http://dx.doi.org/10.1590/S0004-27302010000200006

More Related