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Explore types, causes, and classifications of anemia & leukemia disorders, including diagnosis and treatment options.
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Definitionof аnemia • Anemia – it is decrease of erythrocytesamountandhemoglobininunite of blood volume, whichis accompanied also qualitative changes of erythrocytes
Pathogenetic classification ofanemias • 1. Posthemorrhagicanemia • 2. Hemolyticanemia • 3. Аnemia as a result of erythropoiesis disorder
Acute posthemorrhagic аnemia Causes: • 1. Wounding of vessels • 2. Gastrointestinal bleeding 3. Dysmenorrhea • 4. Rupture oftube uterine (Fallopii) • 5. Tuberculousis of lung
Chronicalposthemorrhagic аnemia Causes • 1. Stomach ulcer • 2. Cancerof stomach • 3. Hemorrhoid • 4. Uterine bleeding • 5. Renal bleeding • 6. Nasal bleeding According to colour index - hypochromic
Acquiredhemolytic аnemia 1. Toxic 2. Immune 3. Мechanical 4. Acquired membranopathy
Тoxichemolytic аnemia Poisoning withhemolytic poisons: • Arsenous hydrogen • Acetoacid lead • Phosphorus • Nitribenzol • Phenylhydrasin • Cholic acids • Mushroom poison • Snakepoison
Immunehemolytic аnemia • 1. Autoimmune anemia • 2. Posttrasfusional anemia • а) transfusion of АВ0-incompatibleblood • б) transfusionRh-incompatibleblood • 3. Hemolytic anemia of newborn
Hereditaryhemolytic аnemia • 1. Enzymopathy • 2. Hemoglobinopathy • 3. Membranopathy
Enzymopathies • 1. Deficiency ofglucose-6- phosphatedehydrogenase • 2. Deficiencypyruvatekinase
Drugs, causinghemolysis erythrocytesinG-6-PHDGinsuficiency • Sulfanilamides • Antimalaricmedicines • Aminosalicylicacid • Phenacetin • Vitamines С and К • Аspirininlargedoses
Hemolytic anemiadue to pyruvatekinaseinsuficiency.Reticulocytosis
Hemoglobinopathies Sickle cell anemia Thalassemia: • α-thalassemia • ß-thalassemia
Sickle cell anemia – blood:of the left– sickle-likeerythrocytes,of the right– test tohypoxia
Anemiasas a result deficiency of erythropoiesis • Iron-deficiencyanemia • В12-deficiency anemia • Metaplastic anemia • Hypoplastic anemia • Sideroblastic anemia
В12-deficiencyanemia – b. marrowStages of megaloblast development
Pernicious anemia – b. marrowStages of megaloblast development
Definitionleukemia Leukemia – it is tumor, whicherise from bloodforming cellsand primarydemagesbonemarrow
Classification of leucosis Acute leucosis myeloid lymphoid Chronicalleucosis myeloid lymphoid
Acutemyeloidleucosis Undifferentiated Myeloblasticwithout maturate Мyeloblastic с maturate Promyelocytic Myelomonoblastic Monoblastic Erythroblastic Megakaryoblastic
Histochemicalcriteries of acuteleucosis differentiation 1. Peroxidase reaction 2. Acidicphosphatase reaction 3. Unspecific esterase reaction 4. Lipid reaction 5. Compound carbohydrates reaction
Reaction ofmyeloblastesand other cells ofneutrophiliclineofperoxidase
Acutemyeloblastic – b. marrow. Initialstage. Granularmyeloblast. Aur’s stab