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Benign Prostatic Hyperplasia. BPH. Benign increase in size of prostate Hyperplasia of stromal and epithelial cells Nodules. Patient W.M. 76 yo Recurrent UTIs Acute pyelonephritis Urinary frequency, urgency, incontinence, and nocturia. Past Medical History. Hypothyroidism COPD Obesity
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BPH • Benign increase in size of prostate • Hyperplasia of stromal and epithelial cells • Nodules
Patient W.M. • 76 yo • Recurrent UTIs • Acute pyelonephritis • Urinary frequency, urgency, incontinence, and nocturia
Past Medical History • Hypothyroidism • COPD • Obesity • 1 ppd smoker • Father – alcoholic • Mother – DM type 2
Review of Symptoms • Strain to initiate urination • Urinary flow stops and then starts • Post-void dribbling
Medications • Ipratropium bromide • Ibuprofen • Levothyroxine • Ferrous sulfate
Case Question 1:For what condition is the patient probably taking ipratroprium bromide?
Ipratropium bromide is used to relieve bronchial spasms • Anticholinergic
Case Question 2:For what condition is the patient probably taking levothyroxine?
IPSS • International Prostate Symptom Score • 8 question survey • Standardize patients
Case Question 3:Based on the patient’s IPSS, is his condition of prostatic enlargement considered mild, moderate or severe?
Case Question 4:Based on the patient’s BMI, is the patient technically overweight or obese?
BMI • Measure of body fat • Underweight < 18.5 • Normal weight = 18.5-24.9 • Overweight = 25-29.9 • Obesity > 30
Vital Signs • Patient’s BMI = 33.8%
Physical Exam • All normal • Urinary Function Tests • Uroflowmetry • Transabdominal ultrasound • Pressure flow study
Case Question 5:Which urinary function test(s) is/are consistent with an enlarged prostate?
Uroflowmetry • Normal: 10 – 21 mL/sec • Patient: 7 mL/sec • Residual Urine Volume • > 50 mL significant • Patient: 110 mL • Bladder Voiding Pressure • Weak < 100 cm H2O • Patient: 74 cm H2O
Case Question 6:Identify all abnormal results of this patient’s urinalysis
Blood Test Results *PSA 13 months ago was 5.0 ng/mL
Case Question 7:Is the patient experiencing an electrolyte imbalance?
8. Renal Function? *PSA 13 months ago was 5.0 ng/mL
9. Hepatic Function? *PSA 13 months ago was 5.0 ng/mL
10. Hb, Hct, MCV, MCH, MCHC? *PSA 13 months ago was 5.0 ng/mL
11. T4 and TSH? *PSA 13 months ago was 5.0 ng/mL
12. Single most significant result? *PSA 13 months ago was 5.0 ng/mL
Case Question 13:Provide three strong lines of evidence that this patient does not have prostate cancer
Low PSA • Physical exam findings • Low WBC count
Case Question 15:When a patient with mild-to-moderate BPH does not respond to pharmacotherapy with 5α-reductase inhibitors or α1-blockers, what can be inferred?