1 / 1

PET-CT predicts survival in muscle i nvasive b ladder c ancer

PET-CT predicts survival in muscle i nvasive b ladder c ancer. No. 116.

roza
Download Presentation

PET-CT predicts survival in muscle i nvasive b ladder c ancer

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. PET-CT predicts survival in muscle invasive bladder cancer No. 116 Laura S. Mertens1 *, Carmen Mir2 *, Andrew M Scott2, Sze-ting Lee2, Annemarie Bruining3, , Erik Vegt4, Wouter V. Vogel4, Rustom Manecksha2, Damien Bolton2, Simon Horenblas1, Ian D Davis2, Bas W.G. van Rhijn1, Nathan Lawrentschuk2 1 Department of Urology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands 2 Department of Surgery, Ludwig Institute for Cancer Research, University of Melbourne, Austin Hospital, Melbourne, Australia 3 Department of Radiology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands 4 Department of Nuclear Medicine, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands * equal contribution Posters Proudly Supported by: Introduction The standard treatment for patients with muscle invasive bladder cancer (MIBC) or treatment refractory non-muscle invasive bladder cancer (NMIBC) is radical cystectomy (RC) including a bilateral pelvic lymph node dissection (PLND) [1-3]. Patients with node-positive disease at PLND have a poor survival. Overall 5- and 10- year survival rates are 78% and 56% for node-negative disease and 31% and 23% for node-positive disease, respectively[3]. Patients with distant metastasis have an even poorer prognosis with cures rarely achieved. Thus, clinical outcome of patients with MIBC critically depends on the presence or absence of extravesical lesions. • Results • Fig 1. Kaplan Meier overall survival estimates of the PET/CT negative versus PET/CT positive patients (P log rank < 0.001). adder washout • Fig 2. Kaplain Meier disease specific survival estimates of the PET/CT negative versus PET/CT positive patients (P log rank < 0.001) Aim To investigate whether metabolic uptake within extravesical tumour deposits on PET/CT predicts survival in muscle invasive bladder cancer (MIBC • Methods • We studied 211 patients from an Australian and a European tertiary oncology center with biopsy-proven MIBC who underwent PET/CT scans for staging purposes. • Data on staging, mortality and surgery were identified from prospective databases. • Patients were divided into PET/CT-positive and PET/CT-negative groups according to the presence of extravesical tumour deposits on the PET/CT study. • Survival was analysed using the Kaplan-Meier method. Multivariable analyses, adjusting for age, hospital and gender, were performed. Acknowledgements We acknowledge the dedication and assistance of the staff in Austin Hospital Melbourne Australiaand NKI Amsterdam, The Netherlands • Conclusions • The presence of extravesical lesions on PET/CT is an independent indicator of reduced survival in patients with MIBC in contrast with conventional staging. • These data may assist for prognosis and treatment selection of patients with MIBC. • If confirmed, PET/CT may be considered in future guidelines to assist staging for patients with MIBC. • . References 1. StenzlA,et al EurUrol 2011; 59(6):1009-1018. 2. HautmannRE, et al Urology 2007; 69(1 Suppl):17-49. 3. Stein JPet al . J ClinOncol 2001; 19(3):666-675.

More Related