CTSI and the Center for Clinical and Translational Informatics CCTI

1. 2006 Deparment of Biomedical Informatics Center for Clinical and Translational Informatics CTSI and the Center for Clinical and Translational Informatics (CCTI) CTSA program emphasized the formation of new transformational structures As part of Biomedical Informatics in CTSI we proposed: Department of Biomedical Informatics (DBMI) � formed 6/14/06 Merged Centers in Pathology, Oncology and Biomedical Informatics Center for Clinical and Translational Informatics (CCTI) � funded Housed in DBMI National and local search for Director Academic, transformational unit formed by integrating GCRC Information Technology Core with caBIG program team Center for Strategic Informatics (CSI) � partially funded by ISD Envisioned as a UPMC Center in liaison with ISD to focus on inter-operability, eRecord and commercialization/industry partnerships New Center for Clinical Informatics (Martich) is the new vision Commercialization/Industry partnerships not part of new vision

3. 2006 Deparment of Biomedical Informatics Center for Clinical and Translational Informatics Center for Clinical and Translational Informatics (CCTI)Specific Aim 1 � Toolkit Development Specific Aim 1 � ��to develop, implement and maintain the most advanced, integrated informatics tools to support research throughout the life cycle of translational research.� Development of a system wide research registry/patient recruitment tool implemented in inpatient, outpatient and physician offices Integration of GCRC Information Technology Core (ITC) and the Cancer Biomedical Informatics Grid (caBIG) team into CCTI DBMI has both Clinical Trials tools and Tissue Banking tools vetted by U Pitt OOR & UPMC CTO for �enterprise� use (including financial modeling and billing support) Use of caBIG Tissue Banking/Pathology Tools in non-cancer areas CCTI integrates Clinical Research Information Service which houses our clinical data repository (MARS, with data from 1982-present) This is the �real� IT goal of the CCTI transformation (from CTSI house analogy)

4. Copyright 2006 Deparment of Biomedical Informatics Center for Clinical and Translational Informatics Specific Aim #2 � ��share, implement and support the �open source� tools utilizing the core architecture in an interoperable grid by using tools developed by the Cancer Biomedical Informatics Grid (caBIG) program.� Implementing an environment (network, hardware, software) to promote interoperability of translational informatics research tools: Core Architecture � Vocabulary, Ontology, Interoperability Tissue Banking, Clinical Research, Trials Tools that �talk� This may be all caBIG architecture or may be more linked to UPMC Interoperability efforts (dB Motion � see recent press release) or probably a hybrid of both approaches This is the �real� Biomedical Informatics goal of the CCTI transformation Center for Clinical and Translational Informatics (CCTI)Specific Aim 2 � Infrastructure Development

5. 2006 Deparment of Biomedical Informatics Center for Clinical and Translational Informatics Center for Clinical and Translational Informatics (CCTI)Specific Aim 3 � Online Research Community (ORC) Specific Aim #3 � ��build a collaborative IT infrastructure and couple it with systematic training in Clinical and Translational Informatics that will significantly enhance the effectiveness and efficiency of the research within CTSI Implementing an Online Research Community (ORC) to promote real time communication and connectivity in the translational research community at Pitt in CTSI Develop and maintain comprehensive, information-rich directories of people, research interests, projects, services Intelligent information routing that both �pushes� information to and �pulls� information from members of the CTSI community Promote and deliver education in clinical and translational informatics that will be strongly linked to the Clinical Research Scholars and Clinical Research Training Programs (CRTP) This is the �real� educational work of the CCTI transformation

6. 2006 Deparment of Biomedical Informatics Center for Clinical and Translational Informatics Center for Clinical and Translational Informatics (CCTI)SWOT � Strengths, Weaknesses, Opportunities & Threats Strengths of CCTI plan Track record of highly used tools from GCRC ITC, caBIG and CRIS Large extramural research portfolio (NCI, NLM, NHLBI, CDC, AHRQ, etc�) to support research while implementing tools DBMI is significant resource and provides critical infrastructure Strong ties to ISD and UPMC eRecord and Interoperability plan Weakness of CCTI plan Estimated that we have only 20% of the resources we need to execute on this plan over the next 5 years Threat of continued silo-ization of informatics resources in centers, institutes, departments and Schools of Health Sciences Three separate and very different architectures, philosophies and �well worn� tools exist in GCRC ITC, caBIG and CRIS which to date have not been integrated

7. 2006 Deparment of Biomedical Informatics Center for Clinical and Translational Informatics Center for Clinical and Translational Informatics (CCTI)SWOT � Strengths, Weaknesses, Opportunities & Threats Opportunities for CCTI plan Strategic partnerships are in place with dBMotion, Cerner, IBM and GE that have at their core IT development for the Health System Intel, Google labs are significant underleveraged assets UPMC is in a position of significant financial strength to assist CCTI Duke, Columbia and OHSU (all funded sites) have pledged to explore dynamic collaboration Threats to the CCTI plan Worse funding environment in the history of the NIH so dependency on industry and UPMC must be accomplished Complexity of the plan and lack of open-mindedness to �aggressive collaboration� between sites Navigation back to �old ways� with national GCRC-centrism leading the way Lack of strategic IT planning with the Medical School and UPMC