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CTSA Translational Science Steering Committee New Committee Member Orientation August 20, 2008

CTSA Translational Science Steering Committee New Committee Member Orientation August 20, 2008. Key Team Members. Executive Team: Geoff Ginsburg (Duke) - Chair Alice Tarantal (UC Davis) - Co-Chair William Martin (NIEHS) - NIH Doug Sheeley (NCRR) - NIH John Harding (NCRR) - NIH

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CTSA Translational Science Steering Committee New Committee Member Orientation August 20, 2008

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  1. CTSA Translational Science Steering CommitteeNew Committee Member OrientationAugust 20, 2008

  2. Key Team Members Executive Team: • Geoff Ginsburg (Duke) - Chair • Alice Tarantal (UC Davis) - Co-Chair • William Martin (NIEHS) - NIH • Doug Sheeley (NCRR) - NIH • John Harding (NCRR) - NIH • Renee Joskow (NCRR) - NIH COC Members: • Frank Arnett (Texas) • Ken Polonsky (Wash U )

  3. Full Committee Meetings • February 2007 - Introduction to the CTSAs • July 2007 - “pathways to translation” and potential workshop • January 2008 - Deliverables for 2008 • March 2008 - Presentation of Pharmacogenetics Research Network (PGRN) and opportunities for CTSAs • May 2008 - Imaging Consortium

  4. Mission of the Committee -2007 “The mission of the CTSA Translational Steering Committee is to develop infrastructure to facilitate advancements of novel translational research and technologies through the CTSA consortium, in collaboration with NIH. This steering committee, working with appropriate communities, aims to foster advances in translational research through bidirectional integration of basic and clinical research to improve health and patient care.”

  5. Reducing the Mission to Practice - 2008 • Focus on T1 research (bench-to-beside-and-back) • Identify translational pathways and resources to guide the CTSAs in T1 research • Proposed Deliverables for 2008 1. Development of a ‘resource directory/inventory’ for the CTSAs 2. Development of a NIH based ‘accelerator’ for Translational Research 3. Dissemination of knowledge across and beyond the CTSAs

  6. Committee ‘Operating Principles’ • Realistic goals and deliverables • Committee members serve as conduits for information dissemination and identify relevant meeting/working group participants • Small subgroups perform specific tasks • Link to consortium oversight committee priorities

  7. Opportunities and Activities Under Discussion • Educating our constituency on T1 pathways for therapeutic, dx, and device concepts. • Highlighting the opportunities that different CTSA's bring to advance T1 research • Facilitation of T1 research through the identification of additional NIH resources • Identifying key areas where standards can be developed that facilitate T1 research • Highlighting the best practices in T1 research

  8. Pathways for Translation Leverage NCI TRWG products (2007): • Risk assessment tools intended to characterize the health status of an individual • Biospecimen-based risk assessment devices • Image-based risk assessment • Interventions intended to change the health status of an individual • Drugs or biologics • Immune response modifiers • Interventional devices • Lifestyle alterations • How best to integrate these models with the CTSAs?

  9. CTSA Translational Resource Directory • Goal: To create a web accessible resource that highlights specific areas of specialization of CTSA sites with descriptions and access information • Working group identified to develop prototype • UC Davis • Duke • Penn • Columbia • Oregon • Yale

  10. NIH Facilitated Resource Identification:The NIH ‘Accelerator’ • Goal: To identify opportunities for the CTSAs via informational sessions on programmatic opportunities sponsored by NIH • Pharmacogenetics Research Network • NCI Translational Research Working Group • NIH Rapid Access to Intervention Development • NIH Small Molecule Screening • NHGRI programs • Imaging consortium

  11. Opportunities to Develop and Disseminate Standards Goal: To enhance the T1 opportunities for the CTSA consortium for cross talk by establishing standards • Imaging • Biospecimen Banking • Bioinformatics analysis of complex data • ‘Omics infrastructure to for clinical research • Pharmacogenomics

  12. Best Practices in T1 Research • Goal: To develop a workshop that would highlight early learnings from T1 research • Pilot projects • What is the best approach to pilot project programs for T1 research? • Common themes and gaps? • What have been the successes? Failures? • DX, RX, Device examples • Lessons learned? Best Practices? • Whitepaper output

  13. 2008 Timeline (Proposed): Activities and Deliverables Workshop - Best Practices and Standards Resource Directory Prototype Goals Whitepapers Info Sessions Jan Jun Jan

  14. Other Opportunities • Technology Rounds - regular series of presentations • Educate clinicians on advanced technologies • Exposure to tools ripe for clinical development • Potential resources for their work • Web-based and archived • Fellows Program – training to bridge divide between technology and clinic • Short-term crossover immersion experiences • Broaden expertise, learn specific skills • Build collaborative relationships • Understand constraints and opportunities • Similar to HHMI Grad to Med Program concept

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