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CBTTC Expansion in China through BGI/CNBC

CBTTC Expansion in China through BGI/CNBC. Charles Bao, Ph.D General Manager BGI Americas Corporation 2017 CBTTC Annual Investigator Meeting May 8th, 2017. BGI Introduction. Established in 1999 with participation in the Human Genome Project

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CBTTC Expansion in China through BGI/CNBC

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  1. CBTTCExpansioninChinathroughBGI/CNBC CharlesBao, Ph.D General Manager BGI Americas Corporation 2017 CBTTC AnnualInvestigator Meeting May 8th, 2017

  2. BGIIntroduction • Established in 1999 with participation in the Human Genome Project • World’s largest genomic organization, experienced in genomic research, commercial NGS services,diagnostics,and sequencer manufacturing

  3. BGIQuickFacts

  4. ChinaNationalGeneBank(CNGBOverview) • Non-profit organization • PublicPrivatePartnership(PPP) • JointedfundedbyStateGovernment,ShenzhenMunicipalgovernmentandBGI • Operated by BGI Research • Missions: • To act as a platform for integrating geneticresources and capabilities • To lead the innovation, exploration and testing of new genomics technologies • To support the development of the life sciences and bio-economy in China • To maintain international competitiveness and influence in globalgenomicscommunity

  5. PlatformandInfrastructure Sequencing Platform (reading) Synthesis and Editing Platform (writing) Biorepository (sample repository) Database (data repository) Living biobank (living speciesrepository) Global collaborations Collaborations over the platforms

  6. CNGB-Biorepository Automatic sample storage system with more than 10 million samples • Chinese unique genetic resources and • sample database of millet • Collected 2,540 millet samples • Sequenced 2,489 samples with 380Gb data • Opened samples and data to cooperative breeding institutions • Theworld’slargestrepositoryofhumanentericbacteria • Selected 17,000 bacterialstrains • Sequenced 2,300strainsampleswith11.5Gbdata • Discovered100+ new species Genomics: Deciphering the gut flora Was named by Nature as “One of the top tem advancements in science and technology in the world”

  7. CNGB-SequencingPlatform BGISEQ-500 The BGI Desktop Sequencer with accuracy, flexibility, speed, simplicity andexpandability Sequencing capacity 150 BGISEQ-500 sequencers, with data output of ~5 PB per year

  8. BGISEQ-500SequencingApplications BGISEQ-500 PE100Demo Data Transcriptome: http://www.ebi.ac.uk/ena/data/view/PRJEB19428 Sample:UHRR（Universal Human Reference RNA） WholeExome: http://www.ebi.ac.uk/ena/data/view/PRJEB19426 Sample:(Genome in a Bottle)HumanDNA-NA12878 WholeGenome: http://www.ebi.ac.uk/ena/data/view/PRJEB19427 Sample:(Genome in a Bottle)HumanDNA-NA12878

  9. CNGB-DataRepositoryandAnalysis Highly efficient network Cloud storage Cloud computing Bio-informatics Data Center • 46opendatabase • 118millionpageviews Aim to establish world’s first multi-omics cloud platform

  10. BGI-OnlineCloudSolution

  11. BGIOnlineDemoCaseforSpeedAnalysis Benchmark:1000 WESwith100XAnalysis completed within 24 hours Start End 21h47min12sec Autism Spectrum DisorderProject:100 WGSwith30XAnalysis completed within 17 hours

  12. OverviewofBeijingTiantanHospital • Founded in 1956, affiliated with Capital Medical University • A large first-class general hospital with neurosurgery specialty • Patient visits steadily increased tallying up to over 1,000,000 outpatient visits and 30,000 inpatient admissions per year • Founded by Dr. Zhongcheng Wang, Neurosurgery Center of Tiantan • Hospital has been recognized as the largest neurosurgical base in the world

  13. NeurosurgicalCenter • Pediatrics • Brain trauma • Spinal cord & column • Supratentorial tumours • Cerebrovascular disease • Pituitary adenoma and subtentorial tumors • Skull base and brain stem tumours • Endoscopy and functional disease • Intracranial diseases associated with ENT • Glioma center • Ward for officials and VIP

  14. NeurosurgicalCenter Over 12,000 operations in 2015, tumor 7569; Vascular diseases 1472; Functional neurosurgery 940; Brain trauma 1,025; Others 834 • 170 Neurosurgeons: • 55 full-time senior professors • 50 associate professors • 65 attending and residences 15 Subdivisons 420 Beds

  15. PediatricNeurosurgery

  16. CNGB–CBTTCcollboration MoreChinese hospitalpartners

  17. CollaborationOutcome • CBTTCglobalnetworkexpansionintoChina • CBTTCdiagnosisandtreatmentstandardavailabletochinesepediatricbraintumorpatients • IncreasedvolumeofdataandclinicalcasefromchinaexpeditesgeneticdiscoveryatCBTTC • EnrichCNGBbiorepositoryanddatabaseresource

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