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Individual Food Choices Affect Tissue Essential Fatty Acids and

Individual Food Choices Affect Tissue Essential Fatty Acids and Eicosanoid Response Intensity. http://ods.od.nih.gov/eicosanoids. http://www.nagoya-cu.ac.jp/eicosanoids. short6 = 18:2n-6 PUFA short3 = 18:3n-3 PUFA long6 = 20:3+20:4+22:4n-6 HUFA

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Individual Food Choices Affect Tissue Essential Fatty Acids and

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  1. Individual Food Choices Affect Tissue Essential Fatty Acids and Eicosanoid Response Intensity http://ods.od.nih.gov/eicosanoids http://www.nagoya-cu.ac.jp/eicosanoids

  2. short6 = 18:2n-6 PUFA short3 = 18:3n-3 PUFA long6 = 20:3+20:4+22:4n-6 HUFA long3 = 20:5+22:5+22:6n-3 HUFA

  3. Dietary Lipids Plasma Lipoproteins Triglycerides Membrane Phospholipids Lipoprotein Lipase Diglycerides Elongation & Desaturation HUFA NEFA Phospholipase (n-3) (n-6) 18C 18C PUFA 20C 20C HUFA 22C 22C HUFA NEFA Acyl-CoA Lipoprotein Remnants Endothelium Eicosanoids Plasma NEFA CO2 + H2O Inflammatory Oxidant Stress LPS Tissue Lipase Adipose Tissue Fat

  4. Disorders with Excessive Omega-6 Eicosanoid Actions Heart Attack Thrombotic Stroke Arthritis Asthma Colitis Headaches Inflammation Menstrual Cramps Metastases Osteoporosis

  5. Four Types of Dietary Essential Fatty Acids 18-carbon omega-6 18:2n-6 18-carbon omega-3 18:3n-3 20-&22-carbon omega-6 20:3, 20:4, 22:4n-6 20-&22-carbon omega-3 20:5, 22:5, 22:6n-3 Predictably maintain the proportion of omega-6 in 20- & 22-carbon acids (HUFA) of tissues - - as a useful surrogate clinical marker. Lands, Am. J. Clin. Nutr. 1995; 61(suppl): 721S-725S.

  6. Individual Food Choices Affect Tissue Essential Fatty Acids and Eicosanoid Response Intensity http://ods.od.nih.gov/eicosanoids http://www.nagoya-cu.ac.jp/eicosanoids

  7. Conditions for which you take aspirin, ibuprofen(Motrin), acetominophen(Tylenol), COX-2 blockers, & NSAID’s all have excessive 6-eicosanoids

  8. HC3=1.5 HC6=1.1 PC3=0.0555 PC6=0.441 HI3=0.004 HI6=0.040 Co=5.0 Ks=0.175

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