1 / 7

CNS Glia

PNS Glia: Schwann sejt; „szatellita” sejtek. Glia. CNS Glia. Makroglia Neuroepitél eredet. Mikroglia Rezidens nyugvó makrofág. Asztroglia. Oligodendroglia. GFAP (S100 b ) (Gln-synth) (GLT-1). MBP, Po, MOgp, O4 (Szénsav-anhidráz) (Gln-synth). Átmeneti, fejlődő glia-alakok:

shelley-whitney
Download Presentation

CNS Glia

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. PNS Glia: Schwann sejt; „szatellita” sejtek Glia CNS Glia Makroglia Neuroepitél eredet Mikroglia Rezidens nyugvó makrofág Asztroglia Oligodendroglia GFAP (S100 b) (Gln-synth) (GLT-1) MBP, Po, MOgp, O4 (Szénsav-anhidráz) (Gln-synth) Átmeneti, fejlődő glia-alakok: PNS szatellita sejtek; CNS radiális glia, parenchyma-progenitorok (?)

  2. „Asztroglia”-GFAP-pozitív központi idegrendszeri sejtek • In vitro: • radiális glia • I. típusú asztroglia • II. típusú asztroglia • reaktív asztroglia • Idegi őssejtek/gliális progenitorok (?) • In vivo: • plazmás asztrocita • rostos asztrocita • II.típusú asztroglia • reaktív asztroglia • tanycita • ependyma (?) • Müller-glia • Begman-glia • radiális glia • felnőttkori őssejtek I.típusú http://rakiclab.med.yale.edu/stock/gallery/HippoNeuNThb.jpg

  3. Pia - ECM Radiális neuroepithel sejt Idegsejt-előalak Radiális glia Laterális indukció / gátlás Szimmetrikus mitózis ECM kamra + Szimmetrikusaszimmetrikus mitózisok Notch Hes ErbB2 BLBP Delta-1 Mash/Ngn1,2 NRG-1 Aszimmetrikus mitózis + G.C. Schoenwolf , 2001

  4. Bordey DV Hansen et al.Nature000, 1-8 (2010) doi:10.1038/nature08845

  5. Csökkent neuron differenciáció,megemelkedett asztroglia képzés az Fbxw7(Notch-ubikvitinálásért felelős ligáz)-deficiensagyban. Matsumoto A et al. J. Biol. Chem. 2011;286:13754-13764 Impairment of neuronal differentiation and enhanced astroglial differentiation in the Fbxw7-deficient brain. A, Bimmunofluorescence analysis of βIII-tubulin (green) and GFAP (red) in primary cultured cells from the cerebrum of Nestin-Cre/Fbxw7+/F (Control) and Nestin-Cre/Fbxw7F/F (Fbxw7 CKO) mice at P0.5. Nuclei were stained blue with Hoechst 33258. Scale bars = 40 μm., **, p < 0.01; ***, p < 0.005; N.S., not significant. C, immunofluorescence analysis of BrdU (green) and Ki67 (red) in the brain of Nestin-Cre/Fbxw7+/F (Control) and Fbxw7 CKO mice at 30 h after labeling with a single pulse of BrdU at E13.25. More BrdU-positive cells had migrated into the Ki67-negative differentiated mantle zone (MZ) of control mice than into that of Fbxw7 CKO mice. Scale bars = 100 μm (left panels) and 50 μm (right panels). D, quantitative analysis of cells positive for BrdU in the mantle zone in experiments similar to that in C. Data are mean ± S.D. from three independent experiments. ***, p < 0.005. E, immunofluorescence analysis of GFAP in the posterior midbrain of Nestin-Cre/Fbxw7+/F (Control) and Fbxw7 CKO mice at P0.5. Scale bars = 100 μm.

  6. deAzevedo et al., 2003. J.Neurobiol.

  7. II. Típusú asztrociták, in vitro

More Related