Examining Research From the TSE Grant Program

1. Examining Research From the TSE Grant Program Eddie Diaz Melissa Hinton Mark Stevenson

2. What will be covered� Project Goal TSE Grant Program Project Objectives Methodology Examples of Case Studies Conclusions & Recommendations

3. Acronyms EPA � Environmental Protection Agency TSE � Technology for a Sustainable Environment NSF � National Science Foundation PI � Principal Investigator TRI � Toxics Release Inventory

4. Project Goal To define an array of outcomes to assess the success of the TSE program, and to use our results to develop case studies in order to identify and document in detail the effects of research conducted by ten PIs who were supported by the TSE program.

5. Overview of the TSE Program Founded by EPA & NSF Established in 1995 Supports Academic Research Goal Statement

6. Evaluation of the TSE Program Conference held in May of 2004 Coordinated by the NSF & EPA Panel comprised of academic and industrial researchers. if the goals of TSE had been achieved whether outcomes had been measurable & effective if a federally funded program is still neededif the goals of TSE had been achieved whether outcomes had been measurable & effective if a federally funded program is still needed

7. Project Objectives:Key Questions What patents, licensing, and startup companies have been produced? What research projects are the PIs currently conducting? How much funding was awarded in addition to the TSE grants in order to further related research?

8. Project Objectives:Key Questions What impact has the TSE program had on the careers of the graduate students? Which technologies developed by the research are being used in industrial practices? Has the research resulted in the reduction of toxic materials and pollution?

9. Flow Chart

10. Selected PIs Dr. Eric Beckman (1995, 2003): Solvents, Alternative Synthesis Dr. George Kraus (1996): Alternative Synthesis Dr. Nancy Ho (1997): Fuel/Energy, Rewenables Dr. Joseph DeSimone (1997, 2001): Solvents, Alternative Synthesis, Electronics Dr. Chao-Jun Li (1997, 2000, 2004): Catalysts, Solvents, Alternative Synthesis

11. Selected PIs Dr. Krzysztof Matyjaszewski (1998, 2001): Catalysts, Solvents, Alternative Synthesis Dr. Fred Ramirez (1998): Reactor/Process Design, EBM Dr. Yushan Yan (1999): Coatings Dr. Valerie Thomas (2001): LCA Dr. Richard Wool (2001): Coatings, Renewables, Adhesives

12. Interviewing Interviews with PIs covered: Further research Patents & licenses Changes in curriculum Publications of findings Interviews with graduate students focused on their work since completing the project.

13. Archival Research Grant application Project reports Published papers Presidential Green Chemistry Challenge Award Program AirData and Scorecard AirData and TRI databases Estimate how effective the technology resulting from the research has been in reducing toxic chemicals and pollutants. AirData and TRI databases Estimate how effective the technology resulting from the research has been in reducing toxic chemicals and pollutants.

14. Quantitative Analysis Our quantitative analysis was used to show potential environmental impacts of the research, the results are potential because: Some research was not used in industry The research that was used cannot be measured yet. Some PIs did not list specific chemicals or toxins affected, or the ones they described specifically weren�t listed in the databases. Some PIs did not list specific chemicals or toxins affected, or the ones they described specifically weren�t listed in the databases.

15. Quantitative Analysis ToolsScorecard Scorecard integrates over 400 scientific and governmental databases Contains data on several chemicals, several come from the TRI database Allows us to select with a range of over 750 industry types while TRI would only allow 28 Most recent data (RY2001)

16. Quantitative Analysis ToolsAirData Less recent data (RY1999) Has additional information we are interested in that cannot be found in Scorecard Industry types are the same as Scorecard (Over 750 Codes)

17. Results: Case Studies Examples Dr. Eric Beckman Dr. Fred Ramirez

18. Dr. Eric Beckman University of Pittsburgh, Chemical Engineering Funded twice by the TSE Purification of proteins from cell broth using Carbon Dioxide Produce propylene acid using generated hydrogen peroxide

19. Dr. Eric Beckman:Academic Impacts Examples of research used in his elective courses although it did not impact curriculum Had several graduate students

20. Dr. Eric Beckman:Citations

21. Dr. Eric Beckman: Industrial Partners Genencor International Materials Co-writing published papers and patents $60,000 to $70,000 funding Lyondell Chemicals & SNF Funding Catalyst preparation Testing Facilities Genencor International, a biotechnology company that focuses on discovering, developing, and selling biocatalysts and other biochemicals, as an industrial partner Lyondell Chemicals funded Beckman between his two TSE grants with 250,000 dollars. For Beckman�s current grant they help with catalyst preparation and characterization, patenting, and in keeping his GC running smoothly. Also SNF, a French company, makes basic chemicals. They provide pilot testing facilities, knowledge on catalysts, and are giving fifty thousand dollars in funding for his three-year grant. Genencor International, a biotechnology company that focuses on discovering, developing, and selling biocatalysts and other biochemicals, as an industrial partner Lyondell Chemicals funded Beckman between his two TSE grants with 250,000 dollars. For Beckman�s current grant they help with catalyst preparation and characterization, patenting, and in keeping his GC running smoothly. Also SNF, a French company, makes basic chemicals. They provide pilot testing facilities, knowledge on catalysts, and are giving fifty thousand dollars in funding for his three-year grant.

22. Dr. Eric Beckman:Patents Completed patents: US Patent 6638749, October 28, 2003. US Patent 6342196, January 29, 2002 US Patent 6596884, July 22, 2003 US Patent 6710192, March 23, 2004. Filed patents: US Patent Application 20040186319, September 23, 2004. ��US Patent 6638749, October 28, 2003. ��US Patent 6342196, January 29, 2002. � US Patent 6596884, July 22, 2003. �US Patent 6710192, March 23, 2004.��US Patent 6638749, October 28, 2003. ��US Patent 6342196, January 29, 2002. � US Patent 6596884, July 22, 2003. �US Patent 6710192, March 23, 2004.

23. Dr. Fred RamirezQuantitative Example Professor at the University of Colorado, Chemical Engineering. Developed a model for an Electric Arc Furnace (EAF) that could be used in the steel industry. After developing his model, he used data from two plants to test it out.

24. Dr. Fred Ramirez: Potential Environmental Impacts Predicts that Carbon Monoxide (CO) emissions could be reduced in both plants by over 90%. We looked at CO emissions in the U.S. to find potential environmental impacts of Ramirez�s research.

25. Dr. Fred Ramirez: Quantitative Results

26. Conclusions & Recommendations Academic Impacts Industrial Impacts Potential Environmental Impacts Recommendations to the TSE program

27. Conclusions:Academic Impacts Many use their research as examples during classes (Kraus, Beckman) Only a couple PIs generated new classes as a result of their research (Li, Wool) All but one (Ho) sponsored at least one graduate student Some worked with faculty outside their departments or institutions (Kraus, Wool)

28. Conclusions:Responses From Graduate Students �Part of my work is improving the model I developed in school.� Sam Matson (worked with Dr. Ramirez, currently employed at an engineering consulting firm) �By working on [the TSE grant], I was able to find a research area that I was passionate about.� Audrey Lee (worked with Dr. Thomas) �The TSE research I did helped make me a polymers expert.� John LaScala (worked with Dr. Wool)

29. Conclusions:Dr. Richard Wool�s Academic Impacts Helped create courses in green engineering and polymer science Collaborated with faculty at University of Delaware, Georgia Tech, Howard, Michigan State, and Colorado State to explore the creation of a national research center for green materials Sponsored 4 graduate students

30. Conclusions: Industrial Impacts Possible contributors to the lack of industrial effects Too recent Too much financial risk (Kraus, Ramirez) Research still theoretical Results were not as beneficial as originally thought (Beckman)

31. Conclusions: Industrial Impacts When an impact has been made Multiple industrial partners (Matyjaszewski, Beckman) One or more patents (Matyjaszewski, Beckman) Further funding (Li, Beckman, Yan) Many PIs do not know (Li), or are not allowed to say (Matyjaszewski), how companies use their research

32. Conclusions:Dr. Krzysztof Matyjaszewski�s Industrial Impacts Was awarded two patents directly related to his atom transfer radical polymerization (ATRP) research Helped create two industrial consortia involving over twenty companies Licensed his ATRP method to six companies

33. Conclusions: Potential Environmental Impacts Estimates of potential impact outdated Actual emissions may have changed Don�t know how much of the emissions are due to traditional technology or process Potential environmental benefits were difficult to determine. Since much of the research�s results have not been adopted, we needed to work with estimates of potential impact. However�Potential environmental benefits were difficult to determine. Since much of the research�s results have not been adopted, we needed to work with estimates of potential impact. However�

34. Conclusions: Potential Environmental Impacts Most estimates focus on production as opposed to use of a product Some PIs did not specify chemicals that would be reduced or removed

35. Recommendations Improvements to TSE Grant Application TSE should have potential PIs indicate as specifically as they can which chemicals could be reduced or removed Should encourage more industrial involvement in research

36. Recommendations Follow-up Procedures Need better publicizing of successful research TSE should maintain contact with PIs, even after research has been completed Should continue this evaluation with other PIs

37. Acknowledgements: Our Liaisons Diana Bauer April Richards Our Advisors Professor Demetry Professor Petruccelli

38. QuestionsorComments?