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Epigenetic Behavior Physiology: Impact of Social Defeat on Offspring Anxiety and Depression

This paper explores the epigenetic changes in behavior and physiology resulting from 10-day social avoidance in males, with a focus on the effects of defeat on offspring anxiety and depression. The study shows that sub-maximal defeat leads to adverse offspring outcomes, especially in males, affecting their endocrine profile and behaviors. The research further delves into the role of corticosterone, VEGF, and the impact of stress on neuronal health and learning. In vitro conception studies shed light on the behavioral outcomes in defeated males. The data suggest a link between paternal defeat and negative offspring behavioral testing results.

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Epigenetic Behavior Physiology: Impact of Social Defeat on Offspring Anxiety and Depression

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  1. Epigenetic content of this paper Behavior Physiology

  2. 10 day defeat Social Avoidance 10 minutes Fight ! 10 days 24 hours

  3. (t2) (t1) without social target t2 = t1 WITH social target

  4. Sub-maximal defeat Social Avoidance 10 minutes Fight ! 3x Z Z Z Z 15 minutes

  5. control control Normal males Defeat Breed offspring Sub-maximal defeat P F 1

  6. P F 1 Normal males Breed “PRE” offspring Behavioral testing Defeat control Breed “POST” offspring Behavioral testing F 2 F 1

  7. Healthy fathers “PRE” offspring Defeat “POST” offspring P F 1 F 2 Anxiety Anxiety Depression Depression

  8. Corticosterone VEGF (vascular endothelial growth factor) Increases after exercise (a good thing) Needed by neurons/vessels to survive Decreased in depression • Increases during stress • Acute increase promotes learning • Chronic increase yields depression • Enjoy in moderation

  9. Healthy fathers “PRE” offspring Defeat “POST” offspring P F 1 F 2 • BAD endocrine profile • Only POST offspring • Only at basal levels • Only males

  10. In Vitro

  11. Conception The kids EPM Locomotion Suc Pref FST Sex Defeated Males In Vitro EPM Locomotion Suc Pref FST

  12. Take home point “Don’t let your mom know she had sex with a loser”

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