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n-3

n-3. n-6. Linoleic acid (LA18:2 ). α -linolenic acid (ALA18:3 ). Δ -6-desaturase. γ -linolenic acid (18:3). Octadecatetraenoic acid (18:4). Elongase. Dihomo - γ - linolenic acid (DGLA 20:3 ). Eicosatetranoic acid (20:4). COX/LOX. Δ -5-desaturase. Arachidonic acid ( AA 20:4 ).

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n-3

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  1. n-3 n-6 Linoleic acid (LA18:2) α-linolenic acid (ALA18:3) Δ-6-desaturase γ-linolenic acid (18:3) Octadecatetraenoic acid (18:4) Elongase Dihomo-γ-linolenic acid (DGLA 20:3) Eicosatetranoic acid (20:4) COX/LOX Δ-5-desaturase Arachidonicacid (AA 20:4) Eicosapentanoic acid (EPA 20:5) Prostaglandins & Thromboxanes (Series 1) COX/LOX COX/LOX Δ-6-desaturase Elongase Prostaglandins & Thromboxanes (series 3), Leukotrienes (series 5) Prostaglandins & Thromboxanes (Series 2), Leukotrienes (series 4) Docasahexanoic acid (DHA, 22:6) Resolvins, protectins, maresins Supplementary Fig. S1

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