AP Biology (An Introduction)

1. AP Biology(An Introduction) Mr. Boswell Room 208

2. CUSTOMARY INTRODUCTION TO COLLEGE BIOLOGY

3. INTRODUCTION TO 21ST CENTURY SCIENCE

4. Molecular Biology Revolution • Have you heard about it? • Increase life span • Increase quality of life • Compare to The Internet

5. Alba – GFP bunny • Expired in 2002 • “Transgenic art” • AP Lab #6

6. Human Genome Project • Completed in 2003 • Joint Genome Institute (Walnut Creek, CA) • Sequenced entire human genome (DNA) • Cost $2.7 billion • 2004, Celera (J. Craig Venter) = $300,000,000 (11%) • 2010, Illumina (San Diego, CA) = $14,500 (0.0005%) • 2013, $1,000 or less (estimate)

8. “We are now part of an early radical biological revolution that will dwarf the industrial revolution.” -- Julian Savulescu (Oxford University)

9. Futurama • Last year – Juan Enriquez video • Now it is outdated

10. 21st Century Therapies • Gleevec – Chronic Myelogenous Leukemia • 1 pill a day • Sprycel & Tasigna • BrCa-1 and BrCa-2 gene tests for breast and ovarian cancer • In 2010, Oncept DNA Vaccine • Canine Oral Melanoma • Transdermal application • June 2010, “siRNA ‘Cure’ for Ebola?” (Geisbert et al.)

11. Venter Institute August 2009 – 1st Genetically Engineered Organism Altered Yeast genome  bacterium May 2010 – Four bottles (ACTG) + signals = Fully functional Mycoplasma mycoides genome Not just engineering bacteria, but creating them

12. http://ung.igem.org/Team_List?year=2011 http://2011.igem.org/Main_Page

13. Tracheal Replacement • Lab made organ implanted for first time • Trachial Cancer patient • Not tissue derived from patient, entirely foreign materials • Made in London, UK  Stockholm, Sweden

16. What does this mean? • 2008 Plastic Surgeons performed 10.2 Million procedures • Corrections, deletions, augmentations, & enhancements • What will happen when you can design organs, limbs, ...?

17. Hugh Herr "When you go into my closet, there are many, many pairs of legs. I have a running pair, I have a bionic walking pair, limbs that are waterproof," he says. "I have various legs to climb mountains and to sense steep ice walls, other feet that wedge into small rock fissures [and] others that stand on small rock edges the width of a coin.” “My biological body will degrade in time…, but the artificial part of my body will improve over time since I can upgrade.” http://www.npr.org/2011/08/10/137552538/the-double-amputee-who-designs-better-limbs

18. iPSCs (Induced Pluripotent Stem Cells)

19. Engineering Humans • Engineering Children • Already determine gender & eliminate some diseases • What amount of intelligence will your child have? • Will you give them the 577R genotype in the ACTN3 gene? • 84% of Africans have it, 49% of Eurasians have it • What about Olympic athletes? • Engineering Adults • Hear ultrasound frequencies • Telescopic vision

20. INTRODUCTION TO AP BIOLOGY

21. Exit Interview Comments • “…take the class only if you enjoy biology or the sciences.” • “If he/she doesn’t wish to go into the field of science, I’d highly dissuade them from taking the course.” • “If a student is only taking a course to have it on her transcript then she will have a horrible time.” • “…you must learn a ton of information in a short period of time.”

22. Page 2 • “AP Biology is nothing like honors Biology.” • “…the teacher should have removed students from the class who were not up to the standards of the course.” • “Some people played on the computer or did not pay attention in class. Why are they still here?”

23. 2010 AP Biology Results •  Pass Rate = 90% • “5”s = 52% • “5” + “4” = 77% • Students = 64

24. Why this class is difficult… 1. Biology knowledge base is deficient  How many years ago did you take Honors Biology? 2. Honors Biology ≠ AP Biology 3. 55 Chapters (1,230 pages) 4. 3 credits vs. 8 credits

25. Why this class not difficult… 1. Clear expectations • Vocabulary & Objectives 2. Information is readily available 3. Course Materials sourced from 3 Biology textbooks 4. Course materials are easily accessible 5. Few complicated concepts

26. What is a College Level Course? • Student-Driven Learning • Role of teacher is to highlight some important points • Will NOT cover every concept in class • “students are expected to work independently outside the class”

30. Class Discussions • You WILL be called on to attempt an answer • I want to hear what you have to say • Make all questions and comments relevant to the content discussion • If your question is off topic, write it down and ask it later

31. INTRODUCTION TO MR. BOSWELL

32. Background • Undergrad: Philosophy & Biochemistry • Masters: Medical Economics & Epidemiology • HHMI (Howard Hughes Medical Institute) Cohort • Inaugural Fellow (2008) @ University of Florida • Translational Medicine Institute (2011) @ UF • AP Summer Institute (2007, 2008, & 2009) • Nova SE, BCPS, and Stanford University • AP Annual Conference (2008) in Seattle, WA

33. Schedule

34. Assignments • Diagnostic Test due by 2:00 am Tonight !!! • Biology: Diagnostic Test – (45 minutes) • http://www.quia.com/quiz/3231852.html • Student Information Survey • http://www.quia.com/sv/540447.html • Any questions on the Student Survey, email me @ bb@ap-bio.com • Due by 2:00 am Tonight !!

35. Assignment (Page 2) • http://www.ap-bio.com • Student Handbook 2011: Printout, Read, & then Sign • Due Wednesday 8/24/11 • Statement of Understanding (Page 4) • Lab Safety Contract (Page 4) • Academic Integrity (Honor Code) (Page 5) • AP Exam Exception (Page 6) • Homework / Summer Project • Due in class Wednesday 8/24/11

36. Assignment (Page 3) • If you have not gotten emails from Mr. Boswell, make sure you add name to email list • Chapters 2 & 3 tomorrow