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Acute Respiratory Insufficiency

Acute Respiratory Insufficiency. DR. NURCAN KIZILCIK. Learning objectives. Definition of acute respiratory insufficiency Diagnosis of acute respiratory insufficiency Causes of acute respiratory insufficiency Clinical and laboratory findings of acute respiratory insufficiency

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Acute Respiratory Insufficiency

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  1. Acute Respiratory Insufficiency DR. NURCAN KIZILCIK

  2. Learning objectives • Definition of acute respiratory insufficiency • Diagnosis of acute respiratory insufficiency • Causes of acute respiratory insufficiency • Clinical and laboratory findings of acute respiratory insufficiency • Treatment of acute respiratory insufficiency

  3. one or both of its gas exchange functions: oxygenation and carbon dioxide elimination Results from inadequate gas exchange • Insufficient O2 transferred to the blood • Hypoxemia • Inadequate CO2 removal • Hypercapnia

  4. Not a disease but a condition Result of one or more diseases involving the lungs or other body systems

  5. Respiratory tract Pump System Lungs Gas exchange Oxygenandcarbondioxidecrossthealveolar-capillarywallbydiffusion. Oxygen is transportedfromthelungstothecellsandcarbondioxide is transportedfromthecellstothelungs. Roussos et al, Eur Respir J 2003;22;suppl 47: 3s-14s Laghi and Tobin, AJRCCM 2003;168:10 Ventilation

  6. Inability to sustain • arterial partial oxygen pressure (PaO2) • and carbon dioxide (PaCO2) pressure • at physiological range

  7. Clinical findings Tachypnea  Dyspnea  Stridor  Wheezing  The use of auxiliary respiratory muscles

  8. Intercostal retractions  Sweating  Hypertension  Mental status changes  Tachycardia / bradycardia

  9. HYPOXIA EVALUATION OF CLINICAL FINDINGS

  10. EVALUATION OF CLINICAL FINDINGS HYPERCAPNIA

  11. Traditionally, respiratory failure is divided into: type 1 and type 2 but these are not practical terms and it is better to think instead of: • Failure to ventilate • Failure to oxygenate • Failure to both ventilate and oxygenate

  12. RespiratoryFailure Lung Failure Pump Failure Gas exchangeProblem Hypoxemia Decrease in ventilation Hypercapnia Roussos et al, Eur Respir J 2003;22;suppl 47: 3s-14s

  13. Laboratory • Hypoxia: pO2 < 60 mmHg • Hypercarbia: pCO2 > 45 mmHg

  14. Most important lab indicator of adequate ventilation is arterial partial carbon dioxide level (PaCO2). The normal value is 35 to 45 mmHg.

  15. Partial arterial oxygen (PaO2) is an indicator of adequate of tissue oxygenation. Normal PaO2: 80-100 mmHg at room air. When decreased below this level, tissue hypoxia may occur.

  16. Respiratory physiology The act of respiration engages 3 processes: 1-Transfer of oxygen across the alveolus 2-Transport of oxygen to the tissues 3-Removal of carbon dioxide from blood into the alveolus and then into the environment Respiratory failure may occur from malfunctioning of any of these processes.

  17. Respiration primarily occurs at the alveolar capillary units of the lungs Fig. 66-1

  18. After diffusing into the blood, the oxygen molecules reversibly bind to the hemoglobin. • 1 g of hemoglobincombines with a maximum of 1.36 mL of oxygen.

  19. The carbon dioxide is transported in 3 main forms: 1- in simple solution 2- as bicarbonate 3-combined with protein of hemoglobin as a carbamino compound.

  20. ETIOLOGY Pulmonary% 52 • Pneumonia % 23.7 • Atelectasis % 15.4 • Chronic obstructive pulmonary disease % 13.7 • Pulmonary edema - cardiogenic %9.2 • Aspiration % 5.7 • Pulmonary edema –non-cardiogenic % 4.9

  21. Non- Pulmonary % 47.9 • Abdominal % 18.4 • Central nervous system % 17.2 • Sepsis % 12.3

  22. Hypoxemic respiratory failure The pathophysiologic mechanisms 1-V/Q mismatch: common cause of hypoxemia 2-Shunt: persistence of hypoxemia despite 100% oxygen inhalation

  23. Common causes of type I (hypoxemic) respiratory failure include the following: • COPD • Pneumonia • Pulmonary edema • Pulmonary fibrosis • Asthma • Pneumothorax • Pulmonary embolism • Pulmonary arterial hypertension • Pneumoconiosis • Granulomatous lung diseases • Cyanotic congenital heart disease • Bronchiectasis • Acute respiratory distress syndrome (ARDS) • Fat embolism syndrome • Kyphoscoliosis • Obesity

  24. Diffusion Limitation Fig. 68-5

  25. NORMAL Neuromuscularcapacity Respiratoryworkload RESPIRATORY FAILURE Neuromuscularcapacity Respiratoryworkload Neuromuscularcapacity Respiratoryworkload Laghi and Tobin, AJRCCM 2003;168:10

  26. Increased respiratory workload : • % 30-50  Inspiratory resistance • %100  Elastic recoil • % 100-200  iPEEP -Bronchoconstriction -Bronchial edema -Pulmonary edema -Pulmonary inflammation

  27. Decreased neuromuscular capacity : • Hyperinflation • Critical illness polyneuropathy • Myopathy • Critical illness myopathy • Sepsis • Ventilator-related muscle damage • Drugs • Metabolic abnormalities • Reduction in the transport of oxygen • Drugs • Muscle fatigue

  28. Patient Evaluation • Adequacy of oxygenation is evaluated with • Pulse oximetry (SpO2) • Arterial blood gas • Adequacy of Ventilation • End-tidal CO2 • Arterial blood gas CO2 • Chest x-ray

  29. Cardiopulmonary Tests • Vital signs and organ perfusion • Blood pressure • Skin symptoms • Consciousness / cooperation • Pneumonia • Congestive Heart Failure • Asthma /COPD

  30. Objectives of clinical evaluation • Detectionandcorrection of life-threateningbloodgasabnormalities • Determination of ventilationrequirements • NoninvasivePositivePressureVentilation • InvasiveMechanicalVentilation • Clarifythecause of respiratoryfailure • Additionaldiagnostictests Sigillito et al, EmergMedClin N Am2003;21:239

  31. TREATMENT • Adequate tissue oxygenation must be ensured Provision airway Adequate ventilation should be started Oxygen therapy Blood transfusion Respiratory depression, muscle and nerve function        discontinued medications that may affect • The primary cause should be treated • Symptomatic treatment

  32. Oxygen Therapy • Nasal cannula • Simple oxygen mask • partial nonrebreathing mask • Non-rebreathing maske • Large volume nebulizer mask

  33. WhenMechanicalVentilation is needed? • PaO2 < 60 mmHg ± PaCO2 > 45 mmHg • Respiratory rate > 30-35 /minute • Abdominal breathing • Rapid shallow breathing • Supporting the use of inspiratory respiratory muscles

  34. Objectives of Mechanical Ventilation • ↑ PaO2 • ↓ PaCO2 • ↓ Acidosis • Unloading of respiratory muscles • Reduce breathlessness

  35. Mechanical Ventilation Treatment Options • Endotracheal intubation + invasive mechanical ventilation • Noninvasive mechanical ventilation

  36. Indications for Intubation • Respiratory arrest • Hemodynamic instability • Confusion • Acute progressive respiratory acidosis • When NIPPV is contraindicated • No response to NIPPV • Hypoxemic patients unresponsive to oxygen therapy

  37. Differential Diagnosis • Pulmonary Diseases • Cardiovascular Diseases • Systemic Diseases

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