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Respiratory System Overview. F ‘08 P. Andrews, Instructor. Respiration and Ventilation - It’s just breathing, isn’t it?. Respiration Exchange of gases between an organism and it’s environment Pulmonary (external) respiration Occurs in lungs Cellular (internal) respiration
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Respiratory System Overview F ‘08 P. Andrews, Instructor
Respiration and Ventilation -It’s just breathing, isn’t it? • Respiration • Exchange of gases between an organism and it’s environment • Pulmonary (external) respiration • Occurs in lungs • Cellular (internal) respiration • Occurs in peripheral capillaries • Is the exchange of respiratory gases between RBCs and tissue • Produces CO2 • Ventilation • The mechanical process that moves air into and out of lungs
The structure • The thorax • Moves air in and out • Oxygen and CO2 are exchanged • Also contains heart, major vessels, trachea, bronchi, lungs, mediastinum
Ventilations are controlled by a series of centers in the brain and blood vessels • Main control center – medulla oblongata • Connected to respiratory muscles via VAGUS NERVE • Additional control center – pons • Apneustic center • Pneumotoxic center
Hering – Breuer reflex – learn it! • Stretch receptors • Decrease inspiratory stimulus
Chemorecepors • In the medulla and carotid bodies and arch of the aorta • Stimulated by changes in O2 and CO2 as well as pH
Hypoxic drive • Hyoxemia is a profound stimulus of respiration in a normal person • People with COPD retain CO2 – have chronically elevated PaCO2 • Peripheral chemoreceptors become used to this; CNS stops using PaCO2 to regulate. • A default mechanism – HYPOXIC DRIVE – is activated • Increased respiratory stimulation when PaO2 falls; inhibited respiratory stimulation when PaO2 climbs
Major muscles of respiration • Intercostal muscles • Diaphragm • Sternocleidomastoid muscles • Accessory muscles are also used • Scalene muscles • Anterior abdominal muscles • Rhomboid muscles • Cough reflex relies on latissimusdorsi muscles
Whew – take a breath! • Sternocleidomastoid muscles • raise upper rib and sternum • Intercostal muscles contract • elevate ribs and increase anterior-posterior dimension • Diaphragm is the primary muscle of respiration – it contracts and flattens • increases volume of cavity. • Pressure in cavity becomes less than atmospheric • air rushes in to alveoli to equalize pressure
Ok…. Breathe out! • Muscles relax… • Diaphragm moves upward • Ribs and sternum move inferiorly • Ribs move closer together in inferior and posterior position • Thoracic volume decreases • Intrathoracic pressure increases
T's all connected! • Changing volume and pressure of thoracic cage also helps with • Pumping blood to and return from systemic circulation • Affects BP and pulse strength • Normally, systolic BP and pulse strength fall during inspiration, rise during exhalation
What's normal? • Adults – 12 – 24 breaths per min. • Children – 18 – 24 breaths per min. • Infants – 40 – 60 breaths per min.
You must also know • Total lung capacity – TLC • ~ 6 L • Tidal Volume – VT • ~ 500 ml (5 – 7 ml/kg) • Dead space volume – VD • ~ 150 ml • Alveolar Volume – VA • ~ 350 ml • Minute volume - Vmin