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SURVEY OF BIOCHEMISTRY Course Review

SURVEY OF BIOCHEMISTRY Course Review. PRS-1. Catalytic efficiency is given by what expression? k cat k cat /K M V max /K M [E] T x k cat. PRS-1. Catalytic efficiency is given by what expression? k cat k cat /K M V max /K M [E] T x k cat. PRS-2.

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SURVEY OF BIOCHEMISTRY Course Review

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  1. SURVEY OF BIOCHEMISTRYCourse Review

  2. PRS-1 • Catalytic efficiency is given by what expression? • kcat • kcat/KM • Vmax/KM • [E]T x kcat

  3. PRS-1 • Catalytic efficiency is given by what expression? • kcat • kcat/KM • Vmax/KM • [E]T x kcat

  4. PRS-2 • Which amino acid is an alpha-helix breaker? • Y • W • V • P

  5. PRS-2 • Which amino acid is an alpha-helix breaker? • Y • W • V • P

  6. PRS-3 • Amino acids are linked by what types of bonds in proteins? • Disulfide bonds • Peptide bonds • Both #1 and #2 • None of the above

  7. PRS-3 • Amino acids are linked by what types of bonds in proteins? • Disulfide bonds • Peptide bonds • Both #1 and #2 • None of the above

  8. PRS-4 • Which cofactors are required for the aldolase reaction? • NAD+ • CoA • FAD • None

  9. PRS-4 • Which cofactors are required for the aldolase reaction? • NAD+ • CoA • FAD • None

  10. PRS-5 • Which of the following is NOT an example of a cofactor? • Glucose • Thiamine Pyrophosphate • Pyridoxal Phosphate • Coenzyme A

  11. PRS-5 • Which of the following is NOT an example of a cofactor? • Glucose • Thiamine Pyrophosphate • Pyridoxal Phosphate • Coenzyme A

  12. PRS-6 • What function does glucagon exhibit? • Increasing glycogen breakdown • Binding to receptors on liver cells • Triggering increased levels of cAMP production • All of the above

  13. PRS-6 • What function does glucagon exhibit? • Increasing glycogen breakdown • Binding to receptors on liver cells • Triggering increased levels of cAMP production • All of the above

  14. PRS-7 • Pyruvate carboxylase converts ___ to _____. • Acetyl CoA to pyruvate • Pyruvate to acetyl Coa • Pyruvate to Oxaloacetate • Pyruvate to Phosphoenolpyruate

  15. PRS-7 • Pyruvate carboxylase converts ___ to _____. • Acetyl CoA to pyruvate • Pyruvate to acetyl Coa • Pyruvate to Oxaloacetate • Pyruvate to Phosphoenolpyruate

  16. PRS-8 • A point mutation in which a purine is replaced by a pyrimidine is called: • Transversion • Transition • Insertion • Deletion

  17. PRS-8 • A point mutation in which a purine is replaced by a pyrimidine is called: • Transversion • Transition • Insertion • Deletion See Section 25-4 From Reading - not mentioned in lecture…

  18. PRS-9 • Which statement is true? • Hemoglobin binding of CO2 stabilizes the T form • The sickle cell form of hemoglobin contains a point mutation (E->V) • 2,3-Bisphosphoglycerate decreases hemoglobin’s affinity for O2 • All of the above

  19. PRS-9 • Which statement is true? • Hemoglobin binding of CO2 stabilizes the T form • The sickle cell form of hemoglobin contains a point mutation (E->V) • 2,3-Bisphosphoglycerate decreases hemoglobin’s affinity for O2 • All of the above

  20. PRS-10 • Which of the following is a unit of O2 pressure? • mm Hg • mol/L • % • nm

  21. PRS-10 • Which of the following is a unit of O2 pressure? • mm Hg • mol/L • % • nm

  22. PRS-11 • See Figure 1. The shift from blue to red indicates: • An increase in pH • A decrease in pH • An increase in hemoglobin concentration • A decrease in hemoglobin concentration

  23. PRS-11 • See Figure 1. The shift from blue to red indicates: • An increase in pH • A decrease in pH • An increase in hemoglobin concentration • A decrease in hemoglobin concentration

  24. PRS-12 • Which are 5-C monosaccharides? • Glucose and ribose • Ribose and fructose • Ribose and mannose • None of the combinations above

  25. PRS-12 • Which are 5-C monosaccharides? • Glucose and ribose • Ribose and fructose • Ribose and mannose • None of the combinations above

  26. PRS-13 • Which reaction is an example of an acid-base catalyzed reaction? • Hexokinase • Pyruvate kinase • Phosphoglucose isomerase • Pyruvate dehydrogenase

  27. PRS-13 • Which reaction is an example of an acid-base catalyzed reaction? • Hexokinase Nucleophilic attack • Pyruvate kinase Nucleophilic attack • Phosphoglucose isomerase • Pyruvate dehydrogenase5-step Reaction

  28. PRS-14 • Which of the following is not a step in the pyruvate dehydrogenase mechanism? • Decarboxylation • Reduction of FAD to FADH2 • Oxidation of NADH to NAD+ • Production of acetyl-CoA

  29. PRS-14 • Which of the following is not a step in the pyruvate dehydrogenase mechanism? • Decarboxylation • Reduction of FAD to FADH2 • Oxidation of NADH to NAD+ • Production of acetyl-CoA

  30. Pyruvate Dehydrogenase Rxn

  31. PRS-15 • Which of the following is not a disulfide reducing agent? • Cysteine • Beta-mercaptoethanol • Lipoic acid • Linoleic acid

  32. PRS-15

  33. PRS-16 • cDNA _____. • Is DNA found in the cytosol of a cell. • Comes from reverse transcription of mRNA. • Stands for “capped” DNA. • Contains the DNA sequence from the entire genome.

  34. PRS-16 • cDNA _____. • Is DNA found in the cytosol of a cell. • Comes from reverse transcription of mRNA. • Stands for “capped” DNA. • Contains the DNA sequence from the entire genome.

  35. PRS-17 • Which are nonpolar amino acids? • Gly, Val, Lys • Arg, Leu, Met • Ile, Pro, Phe • Ala, Met, Ser

  36. PRS-17 • Which are nonpolar amino acids? • Gly, Val, Lys • Arg, Leu, Met • Ile, Pro, Phe • Ala, Met, Ser

  37. PRS-18 • Beta sheets can contain _____. • Antiparallel strands • Parallel strands • Interstrand H-bonds • All of the above.

  38. PRS-18 • Beta sheets can contain _____. • Antiparallel strands • Parallel strands • Interstrand H-bonds • All of the above.

  39. PRS-19 • The hydrophobic effect is driven by ______. • Enthalpy • Entropy • The concentration of water • Temperature

  40. PRS-19 • The hydrophobic effect is driven by ______. • Enthalpy • Entropy • The concentration of water • Temperature

  41. PRS-20 • Which is a major component of brain lipids? • Fatty acids • Triglycerides • Gangliosides • Phospholipids

  42. PRS-20 • Which is a major component of brain lipids? • Fatty acids • Triglycerides • Gangliosides • Phospholipids

  43. Reminders • Final exam is closed-book. • Bring a calculator. • Study by: • Reading the text • Reviewing suggested HW problems • Reviewing What You Should Know summaries (no more added) • Reviewing past exams • Studying lecture notes

  44. CETL Course Survey(s) • Course-Instructor Opinion Survey (CIOS) • http://www.coursesurvey.gatech.edu • Also on T-Square Home Page • Pilot Survey • Go to T-Square: Announcements for link to survey • Focus groups to learn more about student opinions • Deadline: August 3, 2008 • IRB Approval requested: minimal risk

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