1 / 21

SURVEY OF BIOCHEMISTRY Glycogen

SURVEY OF BIOCHEMISTRY Glycogen. 2 Ways To Generate Glucose. Glycogenolysis. Gluconeogenesis. Break down of glycogen. Synthesis of glucose from non-carb precursors. Glucose 1-Phosphate. Glucose. Pyruvate. Lactate. Glucose 6-Phosphate. Energetics of Reversing Glycolysis.

ekram
Download Presentation

SURVEY OF BIOCHEMISTRY Glycogen

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. SURVEY OF BIOCHEMISTRYGlycogen

  2. 2 Ways To Generate Glucose Glycogenolysis Gluconeogenesis Break down of glycogen Synthesis of glucose fromnon-carb precursors Glucose1-Phosphate Glucose Pyruvate Lactate Glucose 6-Phosphate

  3. Energetics of Reversing Glycolysis Reversing glycolysis is not energetically feasible! Hexokinase ∆G° = -17 kJ/mol Glucose Phosphofructokinase ∆G° = -14 kJ/mol PyruvateKinase ∆G° = -31 kJ/mol Pyruvate Ref: Rodney Boyer Interactive Concepts in Biochemistry

  4. Pyruvate to Phosphoenolpyruvate • Dilemma: • Oxaloacetate can only be generated from pyruvate in the mitochondria • Pyruvate gets synthesized initially in the cytosol

  5. PEP and Oxaloacetate Transport Fig 16-20 does not show pyruvate! Draw another viewof this process thatmay be more helpful

  6. Gluconeogenesis

  7. Energetics Revisited ∆G value comparisons By what mechanisms do these enzymes work?

  8. Pyruvate Carboxylase Cofactor

  9. Enzyme-Cofactor Complex

  10. Pyruvate Carboxylase

  11. Pyruvate Carboxylase

  12. PEPCK Mechanism

  13. Ch. 16 Overview • 16-1 Glycogen Breakdown (Fri) • 16-2 Glycogen Synthesis (Wed) • 16-3 Control of Glycogen Metabolism (Wed) • 16-4 Gluconeogenesis (Mon)

  14. Enzymes in Glycogen Synthesis • UDP-Glucose Pyrophosphorylase • Glycogen Synthase • Glycogen Branching Enzyme

  15. UDP-Glucose Pyrophosphorylase UDP-GlucosePyrophosphorylase activates glucosylunits PPi

  16. Glycogen Synthase

  17. Glycogen Branching Enzyme

  18. Overview

  19. PRS • Which of the following enzymes is involved in gluconeogenesis? • Pyruvate carboxylase • Pyruvate kinase • Phosphofructokinase • Glycogen synthase

  20. PRS • Which of the following is not a product of glycolysis? • Pyruvate • Fructose 1,6-Bisphosphate • Oxaloacetate • Glucose 6-Phosphate

  21. PRS • Which enzyme produces glucose 1-phosphate? • Hexokinase • Glycogen Debranching Enzyme • Glycoen Branching Enzyme • Glycogen Phosphorylase

More Related