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FIXa

•. •. •. •. TF. •. TF. FVIIa. FIX. FIXa. FIX. INITIERINGSKOMPLEKS. ?. PROTROMBINASE-KOMPLEKS. TENASEKOMPLEKS. FXa. FX. FXIa. FVII. •. •. •. •. FVa. FVIIIa. FII. FX. FIIa. FIIa. FIIa. FIIa. FIIa. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. FIXa. FXa.

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FIXa

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  1. • • • • TF • TF FVIIa FIX FIXa FIX INITIERINGSKOMPLEKS ? PROTROMBINASE-KOMPLEKS TENASEKOMPLEKS FXa FX FXIa FVII • • • • FVa FVIIIa FII FX FIIa FIIa FIIa FIIa FIIa Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ FIXa FXa FXa FVIIa FVIIa Ca2+ Ca2+ Ca2+ Ca2+ FXIII FIIa FIIa FIfibrinogen FIafibrinmonomer FXIIIa XLFkrydsbundet FIa FIafibrinpolymer TF TF Initiering:Dannelse af initieringskompleks TF FV Spørgsmål omkring trombindannelse på celler FXI Priming og progrediering:Dannelse af tenasekompleks og protrombinasekompleks FVIII:vW

  2. FV • FVIIa • • TF • FIIaFIIaFIIaFIIa FIX • FV FXI FXIa FVII • • • • • • • FVa FVa FVIII FVIIIa FX FX FVII FII FII FIIa FIIa FIIa FIIa FIIa PAR Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ FXa FXa FIXa FXa FXa FVIIa Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ FXIII FIIa FIIa Antikoagulation og fibrinolyse via TM og TAFI FXIIIa FIX FIfibrinogen FIafibrin XLFkrydsbundet fibrin FIXa Initiering:Dannelse af initieringskompleks TF TF Priming og dannelse aftenase- og protrombinase-kompleks TF TrombindannelseHoffman, Monroe Progrediering:Trombindannelse Monroe DM, Hoffmann M, Roberts HR.: Platelets and thrombin generation (art 6)

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